摘要
目的检测胃癌组织中p-STAT3、Bcl-2的表达,探究p-STAT3在胃癌诊断中的临床意义。方法采用免疫组织化学SABC法检测40例胃癌及慢性萎缩性胃炎胃组织中p-STAT3和Bcl-2的表达情况。结果 p-STAT3在40例胃癌组织中阳性表达率达95.0%,慢性萎缩性胃炎胃组织阳性表达率为12.54%,两者之间有显著差异(P<0.05)。Bcl-2在胃癌组织中的表达也明显高于慢性萎缩性胃炎组织(P<0.05),其表达与p-STAT3的表达呈正相关。结论 p-STAT3的过度表达在胃癌发生发展中起重要作用,p-STAT3作为一种新的标记物对胃癌诊断具有重要价值,STAT3可能是通过调节Bcl-2的表达发挥抗凋亡作用。
Objective To study the expression of p-STAT3,Bcl-2 and explore the clinical value of p-STAT3 in the diagnosis of gastric cancer.Methods The expression of p-STAT3 and Bcl-2 were detected by immunohistochemistry method in 40 cases of gastric cancer and chronic atrophic gastritis.Results The expression of p-STAT3 was located in the nucleus of cells.Expressions of p-STAT3 in gastric cancer tissue were higher than that in gastritis tissue and normal gastric mucosa tissues（P〈0.05）.Significantly positive correlation was found between the expression of p-STAT3 and Bcl-2.Conclusion The expression of p-STAT3 is related with the progression of gastric cancer and it might serve as significant predicting factors for this disease.
出处
《中国现代医药杂志》
2010年第10期1-3,共3页
Modern Medicine Journal of China
基金
陕西省科技厅自然科学研究基础项目(编号:2010JM4023)
