硫酸依替米星与思密达联合治疗急性细菌性痢疾的疗效观察

Clinical effects of combination therapy of etimicin sulfate and montmorillonite powder on acute bacillary dysentery

目的观察硫酸依替米星和思密达(化学名:蒙脱石)联合治疗急性细菌性痢疾的临床效果。方法将入选的326例急性细菌性痢疾患者随机分为治疗组182例和对照组144例,治疗组给予硫酸依替米星0.2 g(加入250 mL生理盐水中)静脉滴注,连续3～5 d,同时联合应用思密达口服(3 g/次,3次/d,首剂加倍);对照组单用硫酸依替米星静脉滴注,观察两组的临床治疗效果。结果治疗组一个疗程的治疗有效(治愈+好转)率为93.96%(171/182),对照组为81.25%(117/144),治疗组治疗有效率明显高于对照组(x^2=6.32,P<0.05);治疗组与对照组的平均疗程分别为(2.04±0.48)d、(3.12±0.71)d,两组比较,治疗组疗程明显缩短(t=2.57,P<0.05)。结论硫酸依替米星静脉用药联合思密达口服治疗急性细菌性痢疾疗效显著,疗程缩短,值得临床推广应用。

Objective To observe the clinical effects of combination therapy of etimicin sulfate and montmorillonite powder on acute bacillary dysentery. Methods Three hundred and twenty-six patients were randomly divided into two groups： 182 patients in treatment group were treated with combination of etimicin sulfate 0. 2 g （added into 250 mL saline solution） intravenous drip for consecutive 3-5 days and montmorillonite powder orally （3 g/time, 3 times/day, the initial dose was doubled） ; 144 patients in control group were treated with etimicin sulfate intravenous drip with the same dose. Clinical therapeutic effect in two groups was observed. Results The clinical effective rates were 93. 96% （171/182） and 81.25% （171/144） in treatment and control group respectively, clinical effective rate in treatment group was significantly higher than that of control group （x^2 = 6. 32, P〈0. 05） ; the average treat- ment course in treatment and control group were （2. 04 ± 0. 48） and （3. 12 ±0. 71）days respectively, the former was obviously shorter than the latter（t = 2. 57, P〈0. 05） . Conclusion Combination therapy of etimicin sulfate and montmorillonite powder is an effective method for acute bacillary dysentery, and can shorten treatment course.