柔肝消癥饮对肝硬化大鼠血一氧化氮和内皮素-1的影响

Effect of Rouganxiaozheng Liquid on the Content of Nitrogen Monoxidum and Endothelin in Serum of Hepatic Cirrhotic Rats

目的:观察柔肝消癥饮对肝硬化大鼠血清一氧化氮(NO)和血浆内皮素-1(ET-1)含量的影响。方法:采用复合因素造模法复制肝硬化大鼠模型,实验分组为正常组、模型组、阳性药(复方鳖甲软肝片)对照组和柔肝消癥饮高、低剂量组。观察柔肝消癥饮对肝硬化大鼠肝组织病理形态学、血清NO和血浆ET-1含量的影响。结果:模型组大鼠出现肝小叶损害,纤维组织增生,假小叶形成;血清NO和血浆ET-1含量以及二者比值显著增加。各治疗组肝脏病理损害较轻,血清NO和血浆ET-1含量以及二者比值明显降低。结论:柔肝消癥饮通过显著抑制肝硬化大鼠血清NO和血浆ET-1水平的异常升高,以达到抗肝硬化的作用。

Objective：To observe the effect of Rouganxiaozheng liquid on the content of nitrogen monoxidum（NO）and endothelin1（ET-1） in serum of hepatic cirrhotic rats.Methods：The model of hepatic cirrhosis were made by composite factor,which were devided into five groups,that is normal group,model group,control group（Fufangbiejiaruangan tablet）,high and low Rouganxiaozheng group,the effect of Rouganxiaozheng on hepatic tissue Pathological histology and the content of NO and ET-1 in serum were observed.Results：Compared with normal group,the normal hepatic lobules in model group were disappeared and fibroplasias formed nodus and false folial;The content of NO and ET-1 in serum were increased obviously.Compared with model group,the pathological histology of each treatment group were improved,the content of NO and ET-1 were decreased apparently.Conclusion：Rouganxiaozheng liquid could obviously decrease the content of NO and ET-1 of cirrhosis rats,and resist hepatic cirrhosis.