壳聚糖的性能、产品及应用

PROPERTIES, PRODUCTS, AND APPLICATIONS OF CHITOSAN

目的对壳聚糖的性能、产品以及应用等现况进行客观详实的分析,探讨影响壳聚糖功能及应用的分子结构参数,揭示其结构和功能之间的相互关系,为该产品的产业发展和科学研究方向提供参考。方法广泛查阅国内外相关文献、专利、医药制品的分析检测以及应用结果等相关资料,并结合作者在医用壳聚糖的研发、产品检验以及产业化生产领域的经验,对壳聚糖的性能、制品以及应用情况进行综合分析。结果对壳聚糖的结构与性能的关系、壳聚糖制品的开发及临床应用状况进行了客观分析,并揭示了其临床应用中可能存在的风险性问题。结论壳聚糖的结构与功能是影响其功能、应用以及成果转化和产业化质量的关键因素,尤其是在产品高度纯化的前提下,其相对分子质量和脱乙酰度是最重要的两个结构参数,在产业化和科学研究中均应重点关注。

Objective To review and analyze the properties, products, and applicauons oi cnltosan so as to explore the key molecular structure parameters which can affect the properties and applications significantly, and to reveal the relationship between molecular structures and properties so as to provide reference for further development of chitosan industry and scientific research. Methods Based on the collection and analysis of related literature, patents and medical products derived from chitosan, as well as the author＇s experiences in research and development, evaluation and standardization of chitosan, the paper was prepared to bring more attentions into the correlativity between structure and properties of chitosan. Results Potential risks in clinical application of chitosan-based preparations were seriously proposed in addition to a scientific review and analysis on relationships between chitosan structure and properties, as well as the present situations of developments and applications of chitosan. Condusion The molecular structure is the crucial factor that can bring not only positive but also passive effects to the properties and applications of chitosan, especially for highly purified chitosan, molecular weight, and deacetylation degree are the most important parameters that should be focused more attention on.