肝病患者血小板参数测定的临床意义

The Clinical Significance of Piatelet Parameters Determination in Patients with Liver Diseases

目的 探讨肝病患者外周血血小板4项参数的变化及其临床意义.方法 应用SYSMEX SF-3000型全自动血液分析仪对不同肝病患者的血小板参数进行了分析,并以健康体检者为正常对照,数据进行统计学分析.结果 重症肝炎与肝硬化组患者PLT、PCT均低于正常对照组（P〈0.01）,而MPV,PDW高于正常对照组（P〈0.01）;原发性肝癌患者PLT,PCT低于正常对照组（P〈0.01）,而高于肝硬化组（P〈0.05）,MPV,PDW均高于正常对照组（P〈0.01）.结论 重症肝炎、肝硬化、原发性肝癌患者外周血小板参数均有所变化,而变化的程度与病情的进展和预后有关,全面综合分析血小板参数的变化情况,在肝病的诊断和治疗上都有着比较重要的意义.

Objective To investigate the changes and their clinical significance of 4 kinds of platelet parameters in blood of patients with liver diseases. Methods Platelet parameters of patients with liver diseases were detcted by SYSMEX SF-3000 type automated hematology analyzer. The healthy cases were chosen as normal control group. The data were carried out statistics analysis. Results The level of PLT and PCT in severe hepatitis group and liver cirrhosis group was lower than normal control group （ P 〈 0.01 ） ;MPV and PDW was higher than normal control group. （ P 〈0.01 ）. PLT,PCT of primary liver cancer group was lower than normal control group （ P 〈0.01 ） ,higher than liver cirrhosis group （ P 〈 0.05 ） ; MPV, PDW of primary liver cancer group was higher than normal control group （ P 〈 0.01 ）. Conclusion The platelet parameters of all the severe hepatitis ,liver cirrhosis and primary liver cancer patients have variation. The degree of variation was related to the progress and prognosis of disease. Overall analysis of platelet parameters＇variation makes sense in the diagnosis and therapy of liver diseases.