首次发病的强迫症患者的认知功能

The study on cognitive function of first-episode obsessive-compulsive disorder

目的探讨首次发病的强迫症患者的认知功能特点。方法采用韦氏智力测验(Wechsler adult intelligence scale,WAIS)、韦氏记忆测验(Wechsler memorys cale,WMS-R)、Stroop测验、连线测验(trail-making test,TMT)A和B、威斯康星卡片分类测验(Wisconsin card sorting test,WCST)对首次发病的强迫症患者30例和正常对照32名进行认知功能评估。结果患者组WMS-R中图片回忆、再认、联想学习等3项成绩均较正常对照组差(P<0.05),而Stroop测验中的读字色测验的错误数和用时、TMT-B时间、TMTB-A时间等4项成绩也差于正常对照组(P<0.05)。此外,患者组WCST中的完成分类数、正确应答数、错误应答数、持续错误数等4项成绩均较正常对照组差(P<0.01)。结论首次发病的强迫症患者存在记忆、注意和执行功能损害。

Objective To examine the characteristics of cognitive function in first-episode patients with obsessive-compulsive disorder（OCD）.Methods The cognitive functions were studied in 30 first-episode OCD patients and 32 normal controls by using Wechsler adult intelligence scale（WAIS）,Wechsler memory scale（WMS-R）,stroop test,trail-making test（TMT）A and B and modified Wisconsin card sorting test（WCST）.Results Patients were impairment at recognition and associative learning （P0.05）.Compared with normal controls,patients were impaired at errors and using time of reacling word colour of stroop,using time of TMT-B and TMT B-A （P0.05）.Patients were still impaired at categories,total corrects,total errors and perseverative errors WCST （P0.01）.Conclusions The first-episode OCD patients are impaired at memory,attention and executive function.