miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-β

miR-142 和 miR-223 作为造血的特定的 microRNAs 被识别了。miR-223 在 myeloid 系开发有关键功能。然而， miR-142 的功能仍然保持不清楚。在这研究，我们发现那 miR-142， miR-223 稀释了造血的房间，和那 miR-223 的增长通过 LMO2-L/-S isoforms 和 CEBP- 尾的起来调整的 miR-142 表示。miR-223 否定地 post-transcriptionally 调整了 LMO2-L/-S isoforms 和 CEBP- 尾，当 CEBP- 尾断然调整了 LMO2-L/-S isoforms 并且否定地两个都 LMO2-L/-S isoforms 调整了 miR-142 时。这些结果揭示一条新奇 miR-223 鈥擟E BP-尾鈥擫M O2 鈥攎i R-142 规章的小径，它在造血作用有枢轴的功能。

miR-142 and miR-223 have been identified as hematopoietic specific microRNAs, miR-223 has crucial functions in myeloid lineage development. However, the function of miR-142 remains unclear. In this study, we found that both miR-142 and miR-223 attenuated the proliferation of hematopoietic cells, and that miR-223 up-regulated miR-142 expression through the LMO2-L/-S isoforms and CEBP-p. miR-223 negatively regulated both LMO2-L/-S isoforms and CEBP-β post-transcriptionally, while CEBP-βpositively regulated the LMO2-L/-S isoforms and both of the LMO2-L/-S isoforms negatively regulated miR-142. These results reveal a novel miR-223--CEBP-β-LMO2-- miR-142 regulatory pathway, which has pivotal functions in hematopoiesis.