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RASSF1A基因甲基化在上皮性卵巢肿瘤中的检测及临床意义 被引量：3

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摘要 卵巢癌是严重威胁女性健康的一种恶性肿瘤,由于缺乏早期诊断方法,70%的患者就诊时已是晚期,5年生存率仅为20%～30%。因此,如何早期诊断卵巢癌已是当前的研究热点。DNA甲基化是肿瘤发生的早期事件,
作者 陈冬丽 陈双郧 冯景 张春莲 刘永珍 赵昌银 郭广玲
机构地区 郧阳医学院附属十堰市太和医院妇科 湖北中医药大学临床医学院 郧阳医学院附属十堰市太和医院检验科
出处 《中国癌症杂志》 CAS CSCD 北大核心 2010年第9期712-714,共3页 China Oncology
基金 湖北省教育厅自然科学重点项目(编号:b200724002) 湖北省教育厅中青年人才项目(编号:Q20082407) 湖北省自然基金项目(编号:2007ABA371)
关键词 卵巢肿瘤 甲基化 RASSF1A基因
分类号 R737.31 [医药卫生—肿瘤]
  • 相关文献

参考文献9

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共引文献13

同被引文献21

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  • 3Lin VW, Shih YL, Lien GS, et al. Pramter gethylation of SFRP3 Is Frequent in HeNtocellular Carcinoma[J]. Dis Markers, 2014: 351863.
  • 4Wang J, Wang B, Chen X, et al. The prognostic value of RASSF1 A promoter hypemethylatien in non-small cell ltm_g carcinoma: a systematic review and metaanalysis [J]. Carcinogenesis, 2011, 32 (3): 411-416.
  • 5Hu L, Chen G, Yu H, et al. Clinicopathological significance of RASSF1A reduced expression and hypermethylation in hepatocellular carcinoma [J]. Hepatol Int, 2010, 4 (1): 423-432.
  • 6Das PM, Singal IR. DNA methylation and cancer[J]. J Clin On- col, 2004, 22(22) : 4632 -4642.
  • 7Tangkijvanich P, Anukulkamkusol N, Suwangool P, et al. Clinical characteristics and prognosis of hepatocellular carcinoma: analysis based on serum alpha- fetopmtein levels[ J]. J Clin Gastmenteml, 2000, 31(4) : 302 -308.
  • 8Lin.YW, Shih YL, Lien GS, et al. Promoter methylation of SFRP3 is frequent in hepatocellular carcinoma [ J ]. Dis Markers, 2014, 2014: 35,1863.
  • 9Wang J, Wang B, Chen X, et al, The prognostic value of RASSF1 A promoter hypermethylation in non - small cell lung carcinoma: a systematic review and metaanalysis [ J]. Carcinogenesis, 2011, 32 (3) : 411 -416.
  • 10Hu L, Chen G, Yu H, et al. Clinicopathological significance of RASSF1A reduced expression and hypermethylation in hepatocellu- lar carcinoma[ J ]. Hepatol Int, 2010, 4 ( 1 ) : 423 - 432.

引证文献3

中国癌症杂志
2010年 第9期

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