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树突状细胞介导的免疫功能紊乱在全身性感染中的作用 被引量：5

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摘要 全身性感染（sepsis）是危重患者重要死因之一,在美国其发病率高达240/10万人,每年因之死亡患者达21.5万[1].目前认为,全身性感染本质是失控的炎症反应,免疫功能紊乱与其发生密切相关[1].树突状细胞（dendritic cells,DCs）在启动和调节免疫应答中起关键作用.
作者 刘军 邱海波
机构地区 东南大学附属中大医院重症医学科
出处 《中华急诊医学杂志》 CAS CSCD 北大核心 2010年第9期1004-1006,共3页 Chinese Journal of Emergency Medicine
基金 江苏省医学领军人才基金资助项目（[2006]50号） 江苏省高校研究生科研创新计划资助项目（CX09B-066Z）
关键词 树突状细胞介导 免疫功能紊乱 全身性感染 CELLS 危重患者 死亡患者 炎症反应 免疫应答
分类号 R392 [医药卫生—免疫学]
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参考文献19

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同被引文献87

  • 1邱海波,许元,姜丽.休克型猪链球菌Ⅱ型感染患者的器官功能衰竭和支持治疗对预后的影响[J].中华急诊医学杂志,2005,14(11):895-899. 被引量：4
  • 2李金宝,邓小明,朱科明.连续性血液净化对多器官功能障碍综合征患者免疫功能的影响[J].中华急诊医学杂志,2007,16(3):279-282. 被引量：15
  • 3Matthay MA, Zemans RL. The acute respiratory distress'syndrome: pathogenesis and treatment [ J]. Annu Rev Pathol, 2011, 6 : 147- 163.
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  • 5Venet F, Huang X, Chung CS, et al. Plasmacytoid dendritic cells control lung inflammation and monocyte recruitment in indirect acute lung injury in mice [J]. Am J Pathol, 2010, 176 (2) : 764-773.
  • 6Lambrecht BN, Hammad H. The role of dendritic and epithelial cells as master regulators of allergic airway inflammation [ J ]. Lancet, 2010, 376 (9743): 835-843.
  • 7Xiang XS, Zhao YZ, Li N, et al. Accumulation of DC in lamina propria induced by FMS-Like tyrosine kinase 3 ligand aggravates the intestinal inflammatory response during endotoxemia [ J ]. Inflammation, 2010, 33 (1) : 34-45.
  • 8hoh T, Obata H, Murakami S, et al. Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats [J]. Am J Physiol Lung Cell Mol Physiol, 2007, 293 (2) : L446-452.
  • 9Wen H, Hogaboam CM, Gauldie J, et al. Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell eytokine profile [J]. Am J Pathol, 2006, 168 (6): 1940-1950.
  • 10Smit JJ, Lindell DM, Boon L, et al. The balance between plasmacytoid DC versus conventional DC determines pulmonary immunity to virus infections [ J ]. PLoS One, 2008, 3 (3): e1720.

引证文献5

二级引证文献18

中华急诊医学杂志
2010年 第9期

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