肠源性内毒素血症:非酒精性脂肪性肝炎的重要危险因素

Intestinal Endotoxemia:An Important Risk Factor of Non-alcoholic Steatohepatitis

非酒精性脂肪性肝病(NAFLD)是指除外酒精和其他明确损肝因素所致的、以肝细胞脂肪变性和脂质沉积为主要特征的临床病理综合征。非酒精性脂肪性肝炎(NASH)是NAFLD病程进展中的主要阶段。近年多项研究发现肠源性内毒素血症与NASH关系密切,本文就肠源性内毒素血症所致的肥胖和肝脏损伤对NASH发生的影响作一综述。

Non-alcoholic fatty liver disease （NAFLD） is a clinicopathologic syndrome characterized by hepatic steatosis and fat deposition in hepatocytes without excessive alcohol intake and other liver injury factors. Non-alcoholic steatohepatitis （NASH） is a main phase of progression in NAFLD. Recently, studies have shown that intestinal endotoxemia is closely related to NASH. This article reviewed the effect of obesity and liver injury induced by intestinal endotoxemia on the development of NASH.