炎症性肠病的抗生素治疗

Antibiotics in Inflammatory Bowel Disease

炎症性肠病(IBD)主要包括克罗恩病(CD)和溃疡性结肠炎(UC),近年越来越多的证据提示肠道细菌在其发病中发挥重要作用。虽然目前尚未发现特异性细菌与IBD的发病相关,但随着现代微生物学的发展以及肠道细菌与IBD研究的进展,发现肠道细菌可能是参与IBD始动和持续的因素。因此,采用抗生素治疗IBD可能是一种有效的治疗措施。本文就抗生素对活动期CD、CD肛周病变、CD术后复发以及活动期UC和囊袋炎的疗效作一综述。

Inflammatory bowel disease （IBD） includes Crohn＇s disease （CD） and ulcerative colitis （UC）, more and more evidences indicate that intestinal flora may play a pathogenic role in IBD in recent years. Although recent studies have not yet shown any specific pathogenic microorganism, however, with the development of microbiology and advances in intestinal flora and IBD, intestinal flora might be the initiating and perpetuating factor of IBD. Therefore, antibiotic treatment may be served as an efficient therapy for IBD. This article reviewed the efficacy of antibiotics in the treatment of active CD, perianal fistulas of CD, postoperative recurrence of CD, as well as in the treatment of active UC and pouehitis.