围产期妇女血清一氧化氮水平变化及临床意义

Change of serum nitric oxide in periperium women and its clinical significance

目的:探讨围产期妇女不同时期血清一氧化氮水平及其临床意义。方法:分别检测非妊娠期及围产期妇女不同时期血清一氧化氮浓度并进行比较。结果:血清一氧化氮浓度在非妊娠期妇女明显低于早、中、晚孕与妊娠足月待产妇女(P均<0.01),也低于足月妊娠临产妇女,但差异无统计学意义(P>0.05);中期妊娠妇女较早孕妊娠妇女明显升高(P<0.01),晚期妊娠妇女有所下降;而临产妇女较足月妊娠待产妇女明显降低(P<0.01),产后妇女明显低于妊娠不同时期(P<0.01)。结论:妊娠期妇女血清一氧化氮水平较非妊娠期升高,且随孕期的发展而变化,参与妊娠的调节作用。

Objective To determine the serum nitric oxide level in different period of periperium and its clinical significance.Methods The serum nitric oxide levels in different perinatal periods were determined and were compared with those in non-pregnant group.Results The serum nitric oxide level in non-pregnancy was significantly lower than that in all periods of pregnancy（P0.01）,and was lower than that of term labor women,but there was no significant difference（P0.05）.The serum nitric oxide level in mid-trimester was significantly higher than that in early pregnancy（P0.01）,and decreased in late trimester serum.The serum nitric oxide level in term labor was significantly lower than that in late-trimester（P0.01）,and was significantly lower in postpartum than that in all the periods of pregnancy（P0.01）.Conclusion The serum nitric oxide level increases in pregnant women,changes with different gestational periods,and takes part in the modulation of pregnancy.