中国人群CTLA-4基因49位点A/G多态性与1型糖尿病关联性的Meta分析

Correlation between CTLA-4 49A/G gene polymorphism and type 1 diabetes in Chinese population:a Metaanalysis

目的评价细胞毒性T淋巴细胞相关抗原4(CTLA-4)基因外显子1上49位点A/G多态性与中国人群1型糖尿病(T1DM)的关联性。方法检索电子期刊数据库,应用RevMan 5.0对入选文献进行Meta分析,并评估发表偏倚。结果共6篇文献纳入研究,包括970例T1DM患者和1098名对照。CTLA-4基因49 A/G位点G等位基因与A等位基因OR值为1.82,95%CI为1.59～2.08,P<0.01;基因型(GG+GA)与AA的OR值为2.66,95%CI为1.97～3.60,P<0.01。Begg’s检验P=0.261,即所纳入研究未发生发表偏倚。结论 CTLA-4基因49位点G等位基因是中国人群T1DM的遗传危险因素之一。

Objective To evaluate the relationship between CTLA-4 49A/G gene polymorphisms and T1DM in Chinese population. Methods A comprehensive search of original article on the relationship between CTLA-4 49A/G gene polymorphism and T1DM in Chinese population was done, and the included studies were analyzed by using RevMan 5.0, and Begg＇s test, odds ratio, heterogeneity and publication bias test were performed. Results Odds ratios of G allele to T allele and genotypes GG＋GA to genotype AA were 1.82 （95% CI： 1.59-2.08, P〈0.01） and 2.66 （95% CI： 1.97-3.60,P〈0.01）, respectively. Begg＇s test revealed no significant bias. Conclusions G allele of CTLA-4 49A/G gene polymorphism confers genetic susceptibility to T1DM in Chinese population.