缺氧诱导因子-1α在胃癌组织中的表达及其与胃癌侵袭性的关系

The Expressions of HIF-1α in Gastric Cancer and its relationship with invasion of Gastric Cancer

目的 研究缺氧诱导因子-1α（HIF-1α）在胃癌组织中的表达及其与胃癌侵袭性的关系.方法 应用免疫组织化学S-P法检测102例胃癌患者病变组织及50例癌旁正常组织中HIF-1α的表达,并分析其与胃癌侵袭性的关系.结果 HIF-1α阳性表达与癌组织浸润深度、淋巴结转移与否有明显的相关性（P〈0.01）,但与胃癌病理类型及组织分化程度无关（P〉0.05）.结论 HIF-1α可作为反映胃癌恶性生物学行为的指标之一.

Objective To study the expressions of HIF-1α in gastric cancer, and to evaluate its relationship with invasion of gastric cancer. Methods The expressions of HIF-1α in gastric cancer（ 102 cases） and normal gastric tissue（50 eases） were evaluated by immunohistochemical technique. The correlation between its expressions and clinical significance were evaluated. Result HIF-1α was correlated with progress of gastric cancer,tumor invasion depth and lymph node metastasis（ P 〈 0.01 ）, but there is no correlation between HIF-1 α, pathology and differentiation of gastric cancer （ P 〉 0.05 ）. Conclusion HIF-1 α could be considered as reference points in evaluating the malignant biological behavior of gastric