盐酸坦索罗辛与氢氯噻嗪联合治疗输尿管结石198例疗效分析

Efficacy of Tamsulosin Combined Hydrochlorothiazide on 198 Patients of Ureteral Calculi

目的:探讨盐酸坦索罗辛药物治疗输尿管结石的效果。方法:将396例输尿管结石患者随机分为两组,每组198例,治疗组应用盐酸坦索罗辛加氢氯噻嗪加左氧氟沙星片,对照组应用左氧氟沙星,每例患者治疗观察期不超过2周,观察结石排出率、结石排出时间、典型肾绞痛再次发生率。结果:治疗组198例中,排出结石167例,排石率为84.34%:对照组198例中排出结石77例,排石率38.88%。治疗组结石排出时间为2～8(5±3)d,对照组8～14(11±3)d。典型肾绞痛再次发生率比较,治疗组7例,占3.53%,对照组为28例,占14.14%。结论:盐酸坦索罗辛用于辅助排出输尿管结石,减少肾绞痛复发,疗效肯定,无毒副反应,便于在广大基层医院推广应用。

Objective：To evaluate efficacy of tamsulosin combined hydrochlorothiazide in the treatment of ureteral calculi.Methods：396 cases with ureteral calculi were randomly divided into two groups（each group of 198 cases）.Treatment group was treated by tamsulosin,hydrochlorothiazide and levofloxacin,while control group was treated levofloxacin only.The time was no more than 2 weeks.We observed the exclusion rate,exclusion time and the recurrence of renal colic.Results：The exclusion rates in the treatment group and control group were 84.34%（167/198）and 38.88%（77/198）respectively.The exclusion time in the treatment group and control group was 2～8 days（5±3）and 8～14 days（11±3） respectively.Typical of the incidence of renal colic again were 3.53% and 14.14% in the treatment group and control group respectively.Conclusion：Tamsulosin can be used to assist the exclusion of ureteral calculi and reduce the recurrence of renal colic.It has good curative effect to popularize.