匹多莫德分散片佐治麻疹的疗效及对T淋巴细胞亚群的影响

The Clinical Effects on the Measles of the Pidotimond Dispersible Tablets with Its Effects on the T Lymphocyte Subsets

目的:探讨匹多莫德分散片佐治麻疹的疗效及对T淋巴细胞亚群的影响。方法:用流式细胞仪测定43例麻疹患儿出疹期T淋巴细胞亚群,其中对照组21例:给予抗病毒、预防感染、对症处理等治疗。另22例作为治疗组:在对照组治疗基础上给予匹多莫德分散片口服,开始2周,每次0.4g(1片),一日2次,随后减为每次0.4g(1片),一日1次,连续用药60d后,均复查T淋巴细胞亚群。结果:麻疹患儿出疹期,CD3+、CD4+显著降低,CD8+显著增高,CD4+/CD8+比例倒置,差异有显著性(P<0.01)。治疗组患儿治疗后退热、咳嗽缓解、肺部啰音减少或消失、时间均较对照组缩短,两组比较差异有显著性(P<0.01)。治疗组患儿CD3+和CD4+较对照组明显升高,治疗组患儿CD8+较对照组明显降低,差异有显著性(P<0.01)。结论:匹多莫德分散片佐治麻疹疗效肯定,值得临床选用。

Objective：To study the clinical effects of the pidotimond dispersible tablets for the measles with its effects on the T lymphocyte subsets.Methods：The levels of the T lymphocyte subsets of the 43 cases with measles were detected by the flow cytometry at the acute herpes onseting,including the control group with 21 cases treated by the antivirus,prohibiting infection,symptomatic treatment and so on.And 22 cases in the treatment group with taking the Pidotimond dispersible tablets on the base treatment of the control group.One pill of 0.4g per time,two times per day at the first 2 weeks.Then reduce to 1 pill of 0.4g per time and 1 time per day.The levels of the T lymphocyte subsets were detected again after 60 days for the continuous medication.Results：At the acute herpes onseting,the levels of CD3＋,CD4＋ decreased markedly,the levels of the CD8＋ raised markedly.The ratio of CD4＋/CD8＋ were reversed.The difference of the two groups were significant（P〈0.01）.It had shorten the term of the abatement of the fever,relieve of cough,abatement or disappear of lung rales in the treatment group compared with the control group.It was significantly different.（P〈0.01）.The levels of the CD3＋,CD4＋ increased markedly in the treatment group compared to the control group.The levels of the CD8＋ decreased markedly in the treatment group compared to the control group.The difference of the two groups are significantly（P〈0.01）.Conclusion：Pidotimond is efficacious for the measles.