甘油果糖联合甘露醇治疗脑水肿的临床研究

The study of glycerin and fructose combined with mannitol in treatment of cerebral edema

目的观察甘油果糖联合甘露醇治疗脑水肿的临床疗效及其对肾功能的影响。方法将自2008年3月至2010年5月来我科治疗的89例脑水肿患者随机分为观察组和对照组,其中观察组45例,给予甘油果糖联合甘露醇治疗,对照组44例,给予甘露醇治疗。观察临床疗效和对肾功能的影响情况。结果观察组和对照组治疗脑水肿的效果相似,差异无统计学意义(P>0.05),但是甘油果糖联合甘露醇能显著减轻对肾功能的损害,差异有统计学意义(P<0.05)。结论甘油果糖联合甘露醇治疗脑水肿与单独使用甘露醇具有相似的临床效果,但是可以明显减轻对肾功能的损害等,不良反应小,值得推广应用。

Objective To observe the therapeutic effect and clinical effect on renal function of glycerin and fructose combined with mannitol in treatment for Cerebral edema.Methods 89 cases of cerebral edema in our department since March 2008~May 2010 were randomly divided into two groups,the observation group（45cases）were treated by glycerin and fructose combined with mannitol,and the control group（44 cases）were treated by mannitol.Observe the clinical effects and the change of the renal function.Results The clinical effect of the observation group and control group was similar,and the difference was not statistically significant（P0.05）;but glycerin and fructose combined with mannitol can significantly reduce renal damage,the difference was statistically significant（P0.05）.Conclusion The effect of glycerin and fructose combined with mannitol in treatment of Cerebral edema is similar to that of mannital given only,but it can significantly reduce the damage to renal function,and the side effect is lower,it is worth to promote.