复方甘草酸苷用于治疗非酒精性脂肪肝炎的临床观察

Clinical observation of compound glycyrrhizin for Non-Alcoholic steatohepatitis

目的观察复方甘草酸苷(美能)治疗非酒精性脂肪性肝炎(NASH)患者各项临床指标的变化,评价美能治疗非酒精性脂肪炎肝患者的有效性及各观察指标的价值。方法对68例非酒精性脂肪肝患者使用复方甘草酸苷注射液40ml,静脉注射,1次/d,连续使用3周;3周后改为口服复方甘草酸苷片,75mg,3次/d,连服3周。记录治疗前和治疗3周、6周后的各项指标包括ALT(谷丙转氨酶)、AST(谷草转氨酶)、GGT(谷氨酰转氨酶)、TC(血清总胆固醇)、TG(甘油三酯)、FBG(空腹血糖)、RDW(红细胞平均分布宽度)。结果提示美能具有较好的保肝、降酶作用,且无明显毒副作用,可以在临床使用;非酒精性脂肪性肝炎患者的RDW与ALT、GGT呈明显正相关,且与病情变化呈正相关。结论美能对NASH治疗有效,RDW也可作为判断NASH病情预后和诊疗的辅助因子。

Objective To observe changes of clinical parameters of compound glycyrrhizin for Non-Alcoholic Steatohepatitis.To evaluate the clinical efficacy of compound glycyrrhizin for Non-Alcoholic Steatohepatitis（NASH）.Methods The 68 cases were treated by 40 ml compound glycyrrhizin injection once-daily,After 3 weeks Intravenous injection,compound glycyrrhizin tablets were taken 75 mg each time and three times each day for 3 weeks.calculate the clinical parameters：ALT,AST,GGT,TC,TG,FBG and RDW,atbefore treatment and after treatment of 3 weeks and 6 weeks.Results compound glycyrrhizin has the effect of Protecting Liver and Reducing Enzyme,safe and can be used in clinical.There was a positive correlation between the RDW of NASH and ALT、GGT,and so was in the disease evolution.Conclusion In the treatment of NASH,compound glycyrrhizin is effective and safe.RDW can be regard as the auxiliary element of prognosis and diagnosis.