微喷技术在生物医药领域的应用

Development of Microinjection Technique in Biomedicine Field

微喷射是微流体控制系统的一个重要组成部分,是微量流体在惯性力与黏性力交替作用下实现的脉冲流动。微喷射流体的驱动技术和与驱动技术相应的微喷嘴制造技术是微喷射过程正常实现所需要的两项关键技术支撑。作为一种新型的工艺,数字化微喷射技术在微机械和微器件制造、医学、生物工程、制药工程等领域获得了一定发展和初步应用。本文从微喷射的原理出发,介绍微喷技术及其应用范围,并结合图例叙述数字化微喷技术在生物芯片微阵列制备、细胞显微注射、药物涂层心脏支架生产、微胶囊制造、可控释放药物制造等生物医药领域的应用及其特点,指出微喷技术发展的研究方向以及应用研究的重要意义。

Microinjection is an integral component of systems to administer microfluids. The pulsating flow of a microfluid is caused by alternations between the inertia and viscous forces. Drive technology and manufacturing technology of micropipettes are two key factors that regulate the microinjection process. The digital microinjection technique has been a focus of much research and development in the fields of micro-machine and microcomponent technology, medicine, biological engineering and pharmaceutical engineering. In this paper, we discuss the recent research and developments in the field of microinjection, and its application. This paper describes the application and features of digital microinjection techniques as they pertain to bio-chip microarray manufacturing, cell microinjection, production of drug-eluting stents, manufacture of microcapsules, and controlled release of pharmaceutical products. The paper reveals the current directions of microinjection research and the importance of applied research in this field.