更昔洛韦联合半导体激光治疗带状疱疹临床研究

Treatment of herpes zoster with ganciclovir and semiconductor laser

目的评价更昔洛韦胶囊联合半导体激光治疗带状疱疹的疗效及安全性。方法将260例带状疱疹随机分为观察和对照两组,观察组137例,以更昔洛韦胶囊联合半导体激光治疗;对照组123例,用更昔洛韦胶囊治疗,两组同时加用维生素B1、维生素B12,比较两组疗效,后遗神经痛发生率及止痛、止疱、结痂时间。结果观察组有效率90.6%,对照组63.5%,差异有显著性(P<0.05);观察组后遗神经痛发生率6.6%,对照组22.0%,差异有显著性(P<0.05);观察组的平均止痛、止疱、结痂时间均比对照组短(P<0.01)。结论更昔洛韦联合半导体激光治疗带状疱疹疗效好,后遗神经痛发生率低,止痛、止疱、结痂时间短。

Objective To evaluate the efficacy and safety of ganciclovir combining with semiconductor laser in treatment of herpes zoster.Methods 260 patients with herpes zoster were divided into observation group and control group.Observation group including 137 cases was treated with semi conductor laser combining with ganciclovir,and control group including 123 cases was treated with ganciclovir.Both groups were treated with VitB1 and VitB12.The efficacy,occurrence of neuralgia,pain relieving,prevention from lump and time to form a scab were compared between two groups.Results There were significances of efficacy and occurrence of neuralgia in treat group（90.6%,6.6%） and control group（63.5%,22%）（both P0.05）.The study showed that the cure rate,total effective rate and the time of vesicle scabbing,pain relieving and the rate of residual neuralgia in observation group were significantly superior to that in control group.Conclusion Semiconductor laser combined with ganciclovir can achieve better therapeutic effect for herpeszoster patients with advantages of safety,quickly working and shortening course.