摘要
EB病毒(EBV)相关的B细胞淋巴增殖是造血干细胞或实体瘤移植后威胁生命的并发症,由于感染EBV的B细胞过度生长,正常由EBV细胞毒T细胞控制。在既往数十年中,采取系列测定外周血标本EBV-DNA负荷,以辅助确定高危患者和早期诊断淋巴增殖。治疗选择包括调控过度生长的、感染EBV的B细胞和EBV细胞毒T细胞反应间的平衡和采取靶向B细胞单克隆抗体或化疗。主要挑战仍然是为了确定优先治疗的指征与综合新的和常规的治疗。
出处
《东南国防医药》
2010年第4期325-329,共5页
Military Medical Journal of Southeast China
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