东菱迪芙治疗吉兰-巴雷综合征的临床观察

Batroxobin for Guillain-Barre syndrome:clinical observation

目的探讨血浆中纤维蛋白原含量下降,是否能促进吉兰-巴雷综合征患者康复。方法 27例GBS患者,随机分为2组,治疗组在发病后除给予丙种球蛋白治疗外,静脉给予东菱迪芙首剂10u,并隔日给予5u,连续用药7次,对照组仅给予丙种球蛋白治疗。观察患者临床症状恢复情况,应用Hughes评分标准对不同时间点的临床神经功能进行评分;定期检测患者神经电生理改变。结果治疗组用药后,其血浆中纤维蛋白原含量明显低于对照组,治疗组在发病180d时Hughes评分明显低于对照组。神经电生理检查发现,在发病90d时,治疗组正中神经及尺神经传导速度较对照组恢复得更快。结论吉兰-巴雷综合征患者急性期血浆中纤维蛋白原含量下降,可能促进了患者神经功能恢复。

Objective To discuss the relationship between the low level fibrinogen and the healing of Guillain-Barre syndrome.Methods All patients were divided into two groups stochastically and treated with intravenous immunoglobulins（IVIg）at a dose of 0.4g/kg body weight per day for 5 days consecutively.In addition,the treatment group was administrated Batroxobin preparation 10u,hereafter 5u every other day,altogether continuously applied drugs for 7 times.The control group only got the IVIg treatment.The patients＇ clinical symptoms at different situation were observed,and the Hughes scale was used to grading the patients＇ clinical nerve function.The neuroelectricity physiology of patients was examined and compared between different groups.Results The fibrinogen levels of the treatment group in blood plasma was lower than the control group obviously.The Hughes grade of the treatment group was lower than the control group obviously 180 days after the onset.Electrophysiological examination showed that the median nerve and ulnar nerve conduction velocity of the treatment group recovered faster than the control group 90 days after the onset.Conclusion The patients of Guillain-Barre syndrome with decreased fibrinogen in blood plasma may promote patients recovery.