摘要
以对氯苯甲醛等为原料,经四步反应得到目的产物4-甲硫基苯乙腈。首先以甲苯为溶剂对氯苯甲醛与甲硫醇钠反应得到4-甲硫基苯甲醛;然后硼氢化钠还原得到4-甲硫基苯甲醇;再与盐酸反应得到4-甲硫基氯苄。最后以二甲亚砜溶剂,与氰化钠反应得到目的产物4-甲硫基苯乙腈。用核磁共振,对产物进行了结构确证。四步总收率为73.9%。
A four-step process for preparing 4-（methylthio） phenylacetonitrile introduced.Firsfly,p-chlorobenzaldehyde reacted with methyl mercaptan sodium in toluene solution to form p-methyl mercaptobenzaldehyde.Secondly,pmethyl mercaptobenzaldehyde was reduced with sodium borohydride into 4-（methylthio） benzyl alcohol.Thirdly,4-（methylthio） benzyl alcohol was converted with hydrochloric acid into 4-（methylthio） benzyl chloride.Finally,4-（methylthio） benzyl chloride was converted with sodium cyanide in the solution of DMSO into 4-（methythio） phenylacetonitrile.The structure of product was indentified by（）～1H NMR spectroscopy.The total yield was above 73.9%.
出处
《化学世界》
CAS
CSCD
北大核心
2010年第10期626-628,共3页
Chemical World
关键词
对氯苯甲醛
甲基硫化钠
4-甲硫基苯乙腈
p-chlorobenzaldehyde
methyl mercaptan sodium
4-（methythio） phenylacetonitrile
