N-乙酰半胱氨酸对慢性阻塞性肺疾病缓解期TNF-α含量及祛痰效果的影响

Effect on N-acetylcysteine on serum tumor necrosis factor-α and eliminating phlegm in patients with of chronic obstructive pulmonary disease in stable stage

目的探讨N-乙酰半胱氨酸(NAC)对慢性阻塞性肺疾病(COPD)缓解期肿瘤坏死因子(TNF)-α含量及祛痰效果的影响。方法将93例COPD缓解期患者随机分为对照组44例和NAC观察组49例。测定两组治疗前、后血TNF-α含量以及对祛痰效果的影响。结果观察组治疗前、后血TNF-α含量分别为(54.48±5.15)ng/L、(46.25±4.96)ng/L,二者比较差异有统计学意义(P<0.01);对照组治疗前、后血TNF-α含量分别为(56.80±6.73)ng/L、(54.24±6.15)ng/L,二者比较差异无统计学意义(P>0.05);观察组治疗后的痰量评分较治疗前下降(P<0.05);对照组治疗前、后痰量评分比较差异无统计学意义(P>0.05)。结论 NAC有抗炎及抗黏液高分泌作用。

Objective To study the effect of N-acetylcysteine（NAC） on tumor necrosis factor-α（TNF-α） and eliminating phlegm in patients with chronic obstructive pulmonary disease in stable stage.Methods 93 chronic obstructive pulmonary disease（COPD） patients were randomly divided into control group（n=44） and treatment group（n=49）.It was additional NAC treatment in patients of treatment group.Results In the treatment group,the levels of TNF-α and the score of sputul quantity after treatment were descreased compared with that at the beginning of treatment by NAC（P〈0.01）;In the control group,the levels of TNF-α and the score of sputul quantity after treatment were no significant difference compared with that at the beginning of treatment（P〉0.05）.Conclusion NAC has functions of Anti-inflammatory and reducing airway mucus hypersecretion.