孟鲁司特治疗毛细支气管炎的疗效及预防喘息反复发作的作用

Curative effect and decreasing the incidence of asthma following bronchiolitis of Montelukast

目的探讨孟鲁司特治疗毛细支气管炎的疗效和预防喘息反复发作的作用。方法将确诊为毛细支气管炎的90例患者随机分为两组,治疗组45例,对照组45例。两组均给予常规治疗,治疗组加用孟鲁司特口服每晚4 mg,共4周,进行为期1年的跟踪随访。结果咳嗽、喘憋消失时间和肺部体征消失时间均短于对照组(P<0.01),且喘息反复发作次数低于对照组(P<0.01)。结论孟鲁司特治疗毛细支气管炎疗效显著,无不良反应,且能预防喘息的发生和反复发作。

Objective To study the curative effect of Montelukast in bronchiolitis and to evaluate the efficiency of montelukast in decreasing the incidence of asthma following brochiolitis.Methods 90 cases bronchiolitis were categorized in two groups,therapy group 45 cases and control group 45 cases,conventional Medical treatment were given in two groups,Montelukast was appendant in therapy group,4mg,qn,4 weeks.The time of follow up was over 1 year.Results The cure rate of therapy group was significant higher than control group（P〈0.01）,the difference had statistical value.Incidence of asthma following brochiolitis with montelukast was less than without montelukast.Conclusion Montelukast can conspicuous increase the therapy effects of bronchiolitis,Montelukast is an effective way to decrease the incidence of asthma following brochiolitis.Using Montelukast is a good way to precaut the asthma following brochiolitis,and it is not adverse reactions.