血液透析滤过辅助治疗尿毒症顽固性高血压疗效观察

Therapeutic effect of hemodiafiltration in treatment of refractory hypertension of uremia patients

目的观察血液透析滤过(HDF)治疗慢性肾功能衰竭(CRF)患者顽固性高血压(RH)的疗效。方法将30例CRF伴RH患者随机分为两组:血液透析(HD)组和HDF组。HD组行每周3次常规HD治疗;HDF组行每周1次常规HD治疗和每周2次HDF治疗。治疗8周后,比较两组患者治疗前及治疗后血压变化情况。结果 HDF组患者血压较治疗前明显下降,且HDF组患者治疗后血压下降较HD组治疗后明显。结论 HDF治疗尿毒症RH效果确切,值得在临床上推广。

Objective To observe the effect of hemodiafiltration（HDF） on the treatment of refractory hypertension in uremia patients.Methods Thirty patients suffered from chronic renal failure（CRF） associated with refractory hypertension were randomly divided into two groups：hemodialysis（HD） group and hemodiafiltration（HDF） group.Patients from HD group were treated three times a week with standard hemodialysis;while an algorithm of standard hemodialysis once a week combined with hemodiafiltration twice a week was applicated to those from HDF group.Blood pressure of the patients from the two groups were compared before as well as 8 weeks after the above-mentioned treatment.Results After treatment,the blood pressure of the patients from HDF group decreased significantly when compared with that before treatment;and the blood pressure of the patients in HDF group also decreased significantly after treatment when compared with that of patients from HD group as well.Conclusion Hemodiafiltration can treat refractory hypertension effectively in uremia patients,which is worthy of popularization clinically.