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平衡超滤加改良超滤对20例婴幼儿体外循环术后肺功能的影响 被引量:2

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摘要 目的观察平衡超滤(BUF)加改良超滤(MUF)对婴幼儿体外循环术(CPB)后肺功能的影响。方法 40例先天性心脏病患儿,随机分成平衡超滤加改良超滤(BUF+MUF)组及常规超滤(CUF)组,各20例。测定两组超滤前、后的HCT,根据血气分析结果及FiO2计算术后2 h的氧合指数(OI),记录两组术后输血量及呼吸机辅助呼吸时间(MAT),分别在手术开始前、CPB结束、术后3、62、4 h采集桡动脉血测定肿瘤坏死因子(TNF-α)、白细胞介素-8(IL-8)。结果 (BUF+MUF)组超滤后的HCT明显高于CUF组,(BUF+MUF)组术后2 h的OI较CUF组高,呼吸机辅助呼吸时间亦明显短于CUF组。停机时及术后各时间点的TNF-α和IL-8水平,(BUF+MUF)组低于CUF组。结论平衡超滤加改良超滤能提高术后HCT及OI,缩短MAT,并能有效降低TNF-αI、L-8的水平,减轻全身炎症反应,使患儿能在术后尽早脱机,减少CPB术后并发症,促进术后肺功能的恢复。
出处 《重庆医学》 CAS CSCD 北大核心 2010年第20期2766-2767,共2页 Chongqing medicine
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  • 1何争鸣,许蓼梅,孙兰英,胡萍.51例死亡病例的体外循环术回顾分析[J].中国医师杂志,2005,7(10):1355-1356. 被引量:1
  • 2Qiu W, Zheng L, Gu H, et al. Comparison between adult and infant lung injury in a rabbit ischemia-reperfusion model [ J ]. J Thorac Cardiovasc Surg, 2008,136(2) :352-359.
  • 3Evans B J, Haskard DO, Finch JR, et al. The inflammatory effect of cardiopulmonary bypass on leukocyte extravasation in vivo [ J ]. J Thorac Cardiovasc Surg, 2008,135 (5) :999-1006.
  • 4Evans B J, McDowall A, Taylor PC, et al. Shedding of lymphocyte function-associated antigen-1 ( LFA-1 ) in a human inflammatory response [J]. Blood, 2006,107(9):3593-3599.
  • 5Kallapur SG, Jobe AH. Contribution of inflammation to lung injury and development [ J]. Arch Dis Child Fetal Neonatal Ed, 2006,91 (1) :132-135.
  • 6Vogt S, Sattler A, Sirat AS, et al. Different Profile of Antioxidative Capacity Results in Pulmonary Dysfunction and Amplified Inflammatory Response After CABG Surgery [ J ]. Journal of Surgical Research, 2007,139 ( 1 ) : 136-142.
  • 7Miranda DR, Gommers D, Papadakos PJ. et al. Mechanical ventilation affects pulmonary inflammation in cardiac surgery patients: the role of the open-lung concept [ J ]. J Cardiothorac Vasc Anesth, 2007,21 (2) :279-284.
  • 8Friedrich B, Schmidt R, Reiss I, et al. Changes in biochemical and biophysical surfactant properties with cardiopulmonary bypass in children [J]. Crit Care Med, 2003,31 ( 1 ) :284-290.
  • 9Schlensak C, Doenst T, Preusser S, et al. Cardiopulmonary bypass reduction of bronchial blood flow : A potential mechanism for lung in- jury in a neonatal pig model [J]. J Thorac Cardiovasc Surg, 2002, 123(6) :1999-1205.
  • 10Markus R, Frank T, Andreas M, et al. Leukocyte activation and phagocytotic activity in cardiac surgery and infection[J]. Cardiovasc Surg,2002,10(5):470.

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