阿立哌唑与奎硫平治疗老年期精神分裂症对照研究

A comparative study of aripiprazole and quetiapine in the treatment of senile schizophrenia

目的:比较阿立哌唑与奎硫平对老年期精神分裂症的疗效和安全性。方法:将86例老年期精神分裂症患者随机分为两组,分别选用奎硫平或阿立哌唑治疗,疗程12周,采用阳性与阴性症状量表(PANSS)及治疗中出现的症状量表(TESS)评定疗效和不良反应。结果:治疗12周后两组PANSS评分较治疗前均显著下降。阿立哌唑组显效率69.76%,有效率88.37%,奎硫平组显效率72.09%,有效率90.70%,两组差异无显著性(P>0.05)。结论:阿立哌唑与奎硫平治疗老年期精神分裂症均有肯定疗效,安全性高。

Objective：To compare the efficacy and safety between aripiprazole and quetiapine in the treatment of senile schizophrenia. Method：86 patients with senile schizophrenia were randomly divided into two groups receiving aripiprazole or quetiapine treatment respectively. The periods of treatment were 12 weeks. The positive and negative symptom scale （ PANSS） and treatment emergent symptom scale （ TESS） were used to evaluate the efficacy and side effects. Results：The two groups showed significant decreases on PANSS score after 12 week＇s treatment. The excellence rate and effective rate was 69. 76% and 88. 37% respectively in aripiprazole group,while 72. 09% and 90. 70% in the quetiapine group. No significant difference was found between the two groups （ P 0. 05） ,both groups had similar side effects. Conclusion：Aripiprazole and quetiapine are effective and safe in the treatment of senile schizophrenia.