期刊文献+

急性心肌梗死患者血糖水平与死亡率:临床研究证据说明了什么 被引量:5

下载PDF
导出
摘要 血糖水平升高是人体对应激状态的正常反应,血糖水平升高幅度在一定程度上代表应激的强度.无论是糖代谢正常者还是2型糖尿病(T2DM)患者,在发生急性心肌梗死(AMI)时受应激激素(糖皮质激素、肾上腺素等)作用,肝糖输出增加,肌肉等外周组织对葡萄糖的利用减少,血糖水平可进一步大幅度增高,继而引发电解质丢失、氧化应激、心肌损伤、血液高凝、炎症反应等一系列病理过程,加重病情,形成恶性循环.因此,医学界迫切需要了解AMI患者血糖水平与死亡率关系 AMI的糖尿病患者和非糖尿病患者血糖水平与死亡率关系 强化胰岛素血糖控制,使患者血糖达到或接近正常范围,是否可能使AMI患者的死亡率降低,从而改善患者预后等问题.
作者 郑刚
出处 《中国心血管杂志》 2010年第5期335-337,共3页 Chinese Journal of Cardiovascular Medicine
  • 相关文献

参考文献6

  • 1Cakmak M,Cakmak N,Cetemen S,et al.The value of admission glycosylated hemoglobin level in patients with acute myocardial infarction.Can J Cardiol,2008,24:375-378.
  • 2Kosiborod M,Inzucchi SE,Krumholz HM,et al.Glucometrics in patients hospitalized with acute myocardial infarction:defining the optimal outcomes-based measure of risk.Circulation,2008,117:1018-1027.
  • 3Naber CK,Mehta RH,Junger C,et al.Impact of admission blood glucose on outcomes of nondiabetic patients with acute STelevation myocardial infarction (from the German Acute Coronary Syndromes[ACOS] Registry).Am J Cardiol,2009,103:583-587.
  • 4Sinnaeve PR,Steg PG,Fox KA,et al.GRACE Investigators.Association of elevated fasting glucose with increased short-term and 6-month mortality in ST-segment elevation and non-STsegment elevation acute coronary syndromes:the Global Registry of Acute Coronary Events.Arch Intern Med,2009,169:402-409.
  • 5池洪杰,张大鹏,杨新春,杨中苏,徐援.高血糖对老年急性ST段抬高心肌梗死急诊介入治疗患者心功能及预后的影响[J].中华心血管病杂志,2009,37(7):595-598. 被引量:14
  • 6郑刚.2型糖尿病强化血糖控制策略的困惑和思考[J].中国心血管杂志,2008,13(5):321-324. 被引量:5

二级参考文献17

  • 1郑刚,张承宗.2型糖尿病治疗模式的改变——从控制血糖到降低心血管疾病死亡率[J].中西医结合心脑血管病杂志,2005,3(4):351-354. 被引量:2
  • 2沈絮华,贾三庆,李宏伟.血糖对直接经皮冠状动脉介入治疗后患者心肌灌注的影响[J].中华心血管病杂志,2006,34(2):138-142. 被引量:22
  • 3American Diabetes Association.Screening for type 2 diabetes.Diabetes Care,2004,27 Suppl 1:S11-S14.
  • 4Gibson CM,Cannon CP,Murphy SA,et al.Relationship of the TIMI myocardial perfusion grades,flow grades,frame count,and percutaneous coronary intervention to long-term outcomes after thrombolytic administration in acute myocardial infarction.Circulation,2002,105:1909-1913.
  • 5Hokama JY,Ritter IS,Davis-Gorman G,et al.Diabetes enhances leukocyte accumulation in the coronary microciroulation early in reperfusian following ischemia.] Diabetes Complications,2000,14:96-107.
  • 6Maciel PT,Pellanda LC,Portal VL,et al.Glycemia and inflammatory markers in acute coronary syndrome:association with late post-hospital outcomes.Diabetes Res Clln Pract,2007,78:263-269.
  • 7Macin SM,Perna ER,Colonel ML,et al.Influence of admission glucose level on long-tenn prognosis in patients with acute coronary syndrome.Rev Esp Cardiol,2006,59:1268-1275.
  • 8Capes SE,Hunt D,Malmberg K,et al.Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes:a systomatic overview.Lancet,2000,355:773-778.
  • 9Braunwald E, Antman EM, Beasley JW. ACC/AHA guidelines for the management of patient with unstable angina and non-ST- segment elevation myocardial infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines ( Committee on the Management of Patient with Unstable Angina). J Am Coll Cardiol, 2000,36:970-1062.
  • 10Stratton IM, Adler AJ, Neil HA, et al. Association of glycaemia with macrovascular and micravascular complications of type 2 diabetes (UKPDS 35 ) :prospective observational study. BMJ,2000, 321:405-412.

共引文献17

同被引文献48

引证文献5

二级引证文献51

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部