沙美特罗替卡松粉吸入剂联合孟鲁司特钠治疗老年AECOPD的临床观察

Clinical observation of elderly patients with AECOPD treated with seretide in combination with montelukast

目的观察沙美特罗替卡松粉吸入剂(商品名:舒利迭)联合孟鲁司特钠治疗老年慢性阻塞性肺疾病急性加重(AECOPD)的临床疗效。方法 61例老年AECOPD患者,随机分为舒利迭联合孟鲁司特钠治疗组31例,对照组30例,治疗14d后,评价所有患者的运动耐力、血气分析与肺功能指标第一秒用力呼气量(FEV1)、第一秒用力呼气量占用力肺活量百分比(FEV1/FVC)。结果对照组与治疗组上述指标均较治疗前改善(P<0.05与P<0.01),但治疗组较对照组改善更为明显(P<0.05),且药物治疗安全性好。结论舒利迭联合孟鲁司特钠治疗老年AECOPD,疗效显著,能降低运动耐力评分、改善血气分析、促进患者肺功能的恢复。

Objective To investigate the clinical efficacy of seretide in combination with montelukast in the treatment of elderly patients with AECOPD. Methods A total of 61 elderly patients with AECOPD were randomly divided into two groups：seretide in combination with montelukast group（n=31）,control group（n=30）. Endurance ratings,blood gas analysis and parameters of pulmonary function（FEV1,FEV1/FVC）of all patients were assessed after 14 days＇treatment. Results Compared with prior treatment, all indicators above of the two group improved a lot（P0.05,P0.01）,but treatment group was even more apparent than control group （P0.05）and with a sustained safety. Conclusions Combined seretide and montelukast has a significant effect on the treatment of elderly patients with AECOPD by decreasing endurance ratings,improving blood gas analysis and promoting the recovery of pulmonary function.