期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

盐酸法舒地尔联合依达拉奉治疗急性脑梗死的疗效观察 被引量：3

下载PDF
导出
摘要 目的观察法舒地尔联合依达拉奉治疗急性脑梗死(ACI)的疗效。方法将344例急性脑梗死患者,分成两组,每组172例。对照组单用依达拉奉30mg静脉滴注,每日2次,连用10天。联合治疗组再加用盐酸法舒地尔30mg静脉滴注,每天1次,连用14天,比较两组治疗前及治疗后14天神经功能缺损评分(NDS)和临床疗效。结果治疗14天后联合治疗组NDS与对照组比较差异有统计学意义(P<0.05),显效率(62.79%),有效率(88.37%)均明显高于对照组(39.53%,69.77%)(P<0.05),两组均未见明显毒副作用。结论盐酸法舒地尔联合依达拉奉较单用依达拉奉治疗ACI疗效显著,无明显不良反应。
作者 龙倩
机构地区 湖南师范大学附属岳阳医院 岳阳市第二人民医院神经内科
出处 《心脑血管病防治》 2010年第5期359-360,共2页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
关键词 法舒地尔 依达拉奉 急性脑梗死
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献10

  • 1Toshima Y,Satoh S,Ikegaki I,et al.A new model of cerebral microthrombosis in rats and the neuroprotective effect of a Rho-kinase inhibitor[J].Stroke,2000,31(9):2245-2250.
  • 2张明,孙晓川.法舒地尔的药理作用及其临床应用的研究进展[J].山西医科大学学报,2007,38(4):369-373. 被引量：71
  • 3Satoh S,Utsunomiya T,Tsurui K,et al.Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage[J].Life Sci,2001,69(12):1441-1453.
  • 4Wettschureck N,Offermanns S.Rho/Rho-kinase mediated signaling in physiology and pathophysiology[J].J Mol Med,2002,80(10):629-638.
  • 5吴建华,方云祥.法舒地尔对大鼠脑缺血再灌注损伤炎症反应的影响[J].中国临床药理学与治疗学,2008,13(4):377-383. 被引量：18
  • 6Doe C,Bentley R,Behm DJ,et al.Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities[J].J Pharmacol Exp Ther,2007,320(1):89-98.
  • 7Rikitake Y,Kim HH,Huang Z,et al.Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection[J].Stroke,2005,36(10):2251-2257.
  • 8Takeda T,Takeda S,Takumida M,et al.Protective effects of edaravone against ischemia-induced facial palsy[J].Auris Nasus Larynx,2008,35(3):321-327.
  • 9Nakamura T,Kume T,Katsuki H,et al.Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats[J].Eur J Pharmacol,2008,586(1-3):151-155.
  • 10Effect of a novel free radical scavenger,edaravone (MCI-186),on acute brain infarction.Randomized,placebo-controlled,double-blind study at multicenters[J].Cerebrovasc Dis,2003,15(3):222-229.

二级参考文献52

  • 1Shimokawa H,Hiramori K,linuma H,et al.Anti-anginal effect of Fasudil,a Rho-kinsse inhibitor,in patients with stable effort angina:A multicenter study[J].J Cardiovasc Pharmacol,2002,40(5):751-761.
  • 2Fukumoto Y,Matoba T,Ito A,et al.Acute vasodilator effect of a Rho-kinase inhibitor,fasudil,in patients with severe pulmonary hypertension[J].Heart,2005,91:391-392.
  • 3Ishikura K,Yamada N,Ito M,et al.Beneficial acute effects of Rho-kinase inhibitor in patients with pulmonary arterial hypertension[J].Circ J,2006,70(2):174-178.
  • 4Masumoto A,Hirooka Y,Shimokawa H,et al.Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans[J].Hypertension,2001,38(6):1307-1310.
  • 5Kishi T,Hirooka Y,Masumoto A,et al.Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure[J].Circulation,2005,111:2741-2747.
  • 6Uehata M,Ishizaki T,Satoh H,et al.Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension[J].Nature,1997,389:990-994.
  • 7Somlyo AP,Somlyo AV.Ca^2+ sensitivity of smooth muscle and non-muscle myosin Ⅱ:Modulated by G proteins,kinases,and myosin phosphatase[J].Physiol Rev,2003,83:1325-1358.
  • 8Wettschureck N,Offermanns S.Rho/Rho-kinase mediated signaling in physiology and pathophysiology[J].J Mol Med,2002,80:629-638.
  • 9Satoh S,Utsunomiya T,Tsurui K,et al.Pharmacological profile of hydroxy fasudil as a selective Rho kinase inhibitor on ischemic brain damage[J].Life Sci,2001,69(12):1441-1453.
  • 10Watanabe Y,Faraci FM,Heistad DD.Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage[J].Am J Physiol Heart Circ Physiol,2005,288(6):2653-2658.

共引文献86

同被引文献24

二级引证文献12

心脑血管病防治
2010年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部