喹硫平、齐拉西酮和氯丙嗪合并碳酸锂治疗躁狂发作的对照研究

A control study of Quetiapine,Ziprasidone and Chlorpromazine Combined with Lithium in the treatment of acute mania

目的:比较喹硫平、齐拉西酮和氯丙嗪分别合并碳酸锂治疗急性躁狂的疗效和安全性。方法:各型躁狂患者随机分为3组,在使用碳酸锂的同时分别联合喹硫平、齐拉西酮和氯丙嗪进行为期8周的治疗。用躁狂评定量表(MRS)评定疗效,副反应量表(TESS)评定不良反应。结果:喹硫平组、齐拉西酮组和氯丙嗪组治疗急性躁狂的疗效有效率分别为84.0%、80.4%和81.3%,三组之间无统计学差异(χ2=0.360,P=0.628);喹硫平与氯丙嗪起效时间相当,而齐拉西酮起效时间迟于喹硫平与氯丙嗪。喹硫平组和齐拉西酮组不良反应轻于氯丙嗪组。结论:喹硫平和齐拉西酮合并碳酸锂治疗急性躁狂疗效好,不良反应少,安全性高。

Objective：To compare the effcacy and safety of Quetiapine,Ziprasidone and Chlorpromazine combined with Lithium in acute mania respectively. Methods：All patients with acute mania according to CCMD -3 were randomly assigned to receive Quetiapine,Ziprasidane and Chlorproma- zine respectively and all of them combined with Lithium. The study lasted for eight - weeks. The efficacy and safety were evaluated with Mania Rating Scale （MRS） and Treatment Emergent Symptom Scale （TESS） respectively. Results：The efficacy rate of Quetiapine group, Ziprasidane group and Chlor- premazine group were 84.0% ,80.4% and 81.3% respectively, there were no differences among three groups（ χ2 = 4.360 ,P = 0.628 ）. And had less side effects. The Ziprasidone group took effect more slowly than those of Quetiapine group and Chlorpromazine group, Quetiapine group was similar to Chlopromazine group. Conclusion：The Quetiapine and Ziprasidane combined with Lithium are curative effects, less adverse reaction and higher security in acute mania.