艾司西酞普兰与奥氮平合并治疗围绝经期抑郁症的对照研究

A comparative study of Escitalopram combined with Olanzapine in the treatment of perimenopausal depressive disorder

目的:探讨艾司西酞普兰合并小剂量奥氮平治疗围绝经期抑郁症的疗效及安全性。方法:将68例围绝经期抑郁症患者随机分为两组,研究组给予艾司西酞普兰合并奥氮平治疗,对照组单用艾司西酞普兰治疗,疗程均为8周。采用汉密尔顿抑郁量表及汉密顿焦虑量表评定临床疗效,副作用量表评定不良反应。结果:治疗8周末两组汉密尔顿抑郁量表及汉密尔顿焦虑量表评分均显著性下降(分别t=2.57和t=2.38,P均<0.05)。研究组起效快,显效率高于对照组(χ2=5.79,P<0.05),两组不良反应均较轻微。结论:艾司西酞普兰合并小剂量奥氮平治疗围绝经期抑郁症起效快,疗效肯定,安全性高,依从性好。

Objective：To explore efficacy of Escitalopram combined with small - dose Olanzapine in treatment of pefimenopausal depressive disorder. Methods： A total of 68 patients with perimenopausal depressive disorder were randomly divided into study group （ escitalopram combined with small - dose Olanzapine） and control group（ Escitalopram alone） for treatment of 8 weeks. The efficacy was assessed with the Hamilton Depression Scale （HAMD） ,the Hamilton Anxiety Scale（HAMA） and adverse reactions with the Treatment Emergent Symptom Scale（TESS）. Results： After 8 - week treat- ment, the scores of HAMD and HAMA in two groups significantly reduced（ t = 2.57 and t = 2.38 , P 〈 0. 05）. Compared with control group, study group took effects more quiekly and had higher effective rate（ χ2 = 5.79,P 〈 0.05）. Side reactions of two groups were mild. Coneluslon： Combination of Escita- lopram and sinail - dose Olanzapine has quicker effect, better effectiveness, higher safety and well compliance in the treatment of perimenopansal depressive disorder.