摘要
A novel magnetic nanocarrier was strategically designed and successfully prepared.Photosensitizer 2,7,12,18-tetramethyl-3,8-di-(1-propoxyethyl)-13,17-bis-(3-hydroxypropyl)porphyrin(PHPP)was encapsulated into polylactic acid(PLA)-coated Fe3O4 nanoparticles.The diameter of nanocarrier is 30-50 nm by transmission electron micrograph(TEM).The encapsulation efficiency of photosensitizer is 27.98% calculated from UV-vis absorption spectra.The nanocarrier shows obvious photocytotoxic activity to Hela299 tumor cells in vitro.
A novel magnetic nanocarrier was strategically designed and successfully prepared.Photosensitizer 2,7,12,18-tetramethyl-3,8-di-（1-propoxyethyl）-13,17-bis-（3-hydroxypropyl）porphyrin（PHPP）was encapsulated into polylactic acid（PLA）-coated Fe3O4 nanoparticles.The diameter of nanocarrier is 30-50 nm by transmission electron micrograph（TEM）.The encapsulation efficiency of photosensitizer is 27.98% calculated from UV-vis absorption spectra.The nanocarrier shows obvious photocytotoxic activity to Hela299 tumor cells in vitro.
基金
National Natural Science Foundations of China(No.30070862,No.30271534)
Shanghai Municipal Natural Science Foundation,China(No.05ZR14002,No.06PJ14001,No.064319020,No.108146)
the FundamentalResearch Funds for the Central Universities,China(No.10D10514)
