HPV感染与宫颈病变的关系分析

Clinical study of the relationship between HPV infection and cervical lesions

目的探讨农村青年和中年妇女宫颈人乳头状瘤病毒(human papilloma virus,HPV)感染情况及其与宫颈病变的关系。方法采用荧光定量聚合酶链式反应(polymerase chain reaction,PCR)方法对来聊城市第三人民医院就诊的农村中青年妇女行宫颈高危型HPV16/18亚型检测和宫颈口病理检查。结果筛选出宫颈病变患者488例。其中青年妇女患者188例,宫颈癌25例,HPV(+)21例,占84.0%;非宫颈癌病变163例,HPV(+)150例,占92.0%。中年妇女患者300例,宫颈癌45例,HPV(+)15例,占33.3%;非宫颈癌255例,HPV(+)105例,占41.2%。宫颈病变与宫颈癌患者中,青年组HPV阳性率均显著高于中年组,差异有统计学意义(P<0.05)。结论农村青年妇女HPV感染率较中年妇女高,对宫颈癌发病影响较大,故应该对青年妇女加强检测,定期随访。

Objective To study the relationship between the human papilloma virus（HPV）infection and cervical lesions on youth and middle-aged women of Liaocheng countryside.Methods The cervical HPV subtype（HPV16/18）and cervical lesions of visiting youth and middle-aged women were examined in Liaocheng the Third People＇s Hospital.Results Totally 488 cases were screened.HPV positive cases were 21 youth cases（84%）in 25 cases with cervical cancer and 150 cases（92%）in 163 cases without cervical cancer among 188 youth patients.While among 300 middle-aged patients,HPV positive cases were 15 cases（33.3%）in 45 cases with cervical cancer and 105 positive cases（41.2%）in 255 cases without cervical cancer.Among all patients with cervical lesions and cervical cancer patients,the positive rate of HPV infection in youth group（YG）was higher than that in middle-aged group（MG）that the difference was significant（P0.05）.Conclusion The infection rate of youth women in countryside was higher than that in middle-aged women that affect the disease incidence,so measures should be taken to monitor the infection condition in youth women and regular follow-up.