一过性黑矇与颈动脉粥样硬化性狭窄的关系

The correlation between amaurosis fugax and carotid atherosclerotic stenosis

目的探讨一过性黑矇与颈动脉粥样硬化性狭窄的关系。方法选择眼科确诊的一过性黑矇和非一过性黑矇患者各80例为调查对象,均行颈动脉彩色超声检查和血液生化检查;比较2组颈动脉硬化程度及相关危险因素的差异。结果高血压史、脂代谢异常史、IMT增厚、颈动脉粥样硬化斑块、斑块分类、颈动脉粥样硬化性狭窄、狭窄程度、狭窄部位与一过性黑矇有关联,OR具有统计学意义(P<0.05)。职业、三酰甘油(TG)、胆固醇(TC)、低密度胆固醇(LDL)、空腹血糖(FPG)、收缩压(SBP)、舒张压(DBP)水平升高及HDL水平降低与一过性黑矇有关联(P<0.05)。多因素非条件Logistic回归分析,发现TG、FPG、SBP水平升高,HDL水平降低及颈动脉粥样硬化性狭窄是一过性黑矇的危险因素,其中有重度颈动脉粥样硬化性狭窄者发生一过性黑矇的危险性比无狭窄者高(P<0.05)。结论颈动脉粥样硬化性狭窄与一过性黑矇的关系密切。

Objective To investigate the correlation between amaurosis fugax and carotid atherosclerotic stenosis. Methods 80 patients with amaurosis fugax identified by ophthalmological examination and 80 patients without amaurosis fugax were enrolled in the study, all the patients were detected by carotid color ultrasonic and laboratory tests, and the degree of carotid atherosclerotic and related risk factors were compared between the two groups. Results The related factors with amaurosis fugax included the profession, history of hypertension, lipid metabolicab normalities, carotid plaques, plaques classification, carotid atherosclerotic stenosis, carotid stenosis degree,narrow site, serum TG levels, TC levels, LDL levels, HDL levels, FPG levels, SBP, the increase of DBP, the decrease of HDL（ P 〈 0.05 ）. The muhifactor non-conditional Logistic regression analysis showed that the increase of TG, FPG, SBP levels, the decrease of HDL and carotid atherosclerotic stenosis were closely correlated with amaurosis fugax,in which, the risk of occurrence of amaurosis fugax in patients with severe carotid atherosclerotic stenosis was higher than those without carotid atherosclerotic stenosis. Conclusion The carotid atherosclerotic stenosis is closely related with amaurosis fugax.