脑靶向性鼻腔给药制剂的系统评价

System Evaluation of Brain-Targeted Nasal Delivery Preparation

目的:评价鼻腔给药作为脑靶向给药的途径之一。方法:通过血脑屏障体外模型的建立、脑内药物浓度评价方法等方面的研究,说明鼻腔给药的优越性。结果:鼻腔给药可以提高药物在脑内的浓度,达到脑靶向给药的目的。结论:脑靶向给药存在的问题仍是对血脑屏障的认识不够深入,随着对血脑屏障的转运机制、脑部与鼻腔的结构相连优势、脑内发病机制认识以及靶向药物在脑内的药物动力学规律的深入研究,脑靶向给药研究必有突破。

Objective： To evaluate intranasal administration as one of the ways of brain-targeted drug delivery system.Method： Showing the advantages of nasal administration through building the in vitro model of blood-brain barrier and researching the evaluation methods of drug concentration in brain.Result：The intranasal administration can increase the concentration of drug in the brain so as to accomplish braintargeted drug delivery.Conclusion：Lack of in-depth understanding of blood-brain barrier is still the major problem existing in the brain-targeted drug delivery system,but with further studies on the transport mechanism of blood-brain barrier,the structural connection between nasal cavity and brain,the pathogenesis in the brain and the pharmacokinetics of brain-targeting drug a breakthrough in the research on brain-targeted drug delivery system can be expected.