鱼腥草注射液与常用输液及抗生素的配伍安全性研究

The Research on Compatibility Safety of Yuxingcao Injection Mixed With Conventional Infusion Fluids and Antibiotics

通过对文献报道的总结发现,鱼腥草注射液所引发的过敏反应常常与其他药物的联合应用有关,其中多为合用抗生素而引起。目前针对鱼腥草注射液的配伍安全性研究主要集中在鱼腥草注射液与常用输液配伍以及与抗生素配伍两方面。鱼腥草注射液与其他药液或注射用液混合后,在混合液的外观、pH值、微粒数以及含量等理化性质方面或稳定,或有不同程度的改变。内毒素含量检测未见有改变的报道。鱼腥草注射液对多种抗生素的体外抑菌作用没有明显影响,而对某些抗生素的体内抗菌作用有协同作用。

Objective： According to reports,allergic response induced by Yuxingcao injection always correlates with drug combination,especially with antibiotics.The research of compatible safety of Yuxingcao Injection focuses on the injection mixed with conventional infusion fluids and antibiotics.The physico-chemical property of the mixture may be stabilizing or may has different changes in pH,particulate counter or content etc.The endotoxin detection does not show positive report.Yuxingcao Injection doesn＇t affect in vitro the bacteriostasis for many antibiotics,but has a synergistic effect on in vivo antimicrobial activity.