摘要
为探讨重离子束(12C6+)治疗皮肤癌的临床疗效及不良反应,对12例患者(志愿者)进行了重离子治疗临床研究。采用100MeV/u重离子束能量,RBE(Relative biologic effectiveness)值2.5-3.0,放疗剂量60-70GyE,单次剂量2.5-5.41Gy,1f/d,连续6-7d的治疗模式。根据治疗后3个月肿瘤大小变化评价近期疗效,由放射治疗肿瘤组(RTOG)按照急性放射损伤分级标准判断急性损伤。随访3月后发现,10位患者局部肿瘤达到完全缓解(CR),2例部分缓解(PR),局部肿瘤靶区仅有1-2级皮肤反应外,均未见其它放疗副反应。研究结果提示,重离子束治疗皮肤癌疗效好,无明显不良反应,显著缩短治疗时间,安全性高。
To observe the clinical efficacy and adverse reactions of skin cancer treated with heavy ion beams(12↑C^6+), 12 patients (volunteers) accepted the clinical therapy.The heavy ion beam energy was 100 MeV/u, RBE (Relative biologic effectiveness) value was 2.5-3.0, and radiation absorbed dose was 60-70 GyE for 6-7 d with 2.5-5.41 Gy/d.Clinical efficacy was valuated by tumor fashion in 3 months after treatment and acute adverse reactions judged by radiation therapy oncology group based on criteria of acute radiation injury.12 patients were followed up for 3 months and detected.Among them 10 patients were completely remitted (CR) and 2 partly remitted (PR).No adverse reaction appeared except that grade 1-2 skin side-effect was observed.It is suggested that heavy ion beams are effective and safe treatment rays to skin cancer.It can shorten treatment time markedly and has no serious adverse reactions.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
2010年第5期316-319,共4页
Journal of Radiation Research and Radiation Processing
基金
甘肃省自然科学基金(3ZS061-A25-096)
2009年甘肃省重离子等射线治疗肿瘤科技创新团队基金(098TTCA009)资助
关键词
重离子束
皮肤癌
临床研究
Heavy ion beam
Skin cancer
Clinical study