老年人短QT间期综合征与恶性心律失常的关系

Relation of short QT interval syndrome and malidignant arrhythmia in a old-aged population

目的:探讨老年人短QT间期综合征(SQTS)与恶性室性心律失常的关系。方法:随机测量72例老年人常规12导联心电图(ECG)QTfc和QTnc间期,根据R-R间期(R-R)和心率(HR)计算校正QT间期(QTfc、QTnc)值。QTfc、QTnc间期值≤300ms为短QT间期,观察短QTfc、QTnc间期与恶性室性心律失常的关系。应用利多卡因、奎尼丁、氟卡尼和除颤器(ICD)治疗,观察预后。结果:QTfc≤300ms的1年内总恶性室性心律失常发生率为72.22%,死亡率为38.89%;QTnc≤300ms总恶性室性心律失常发生率为72.22%%,死亡率为38.89%;利多卡因转律83.33%;奎尼丁、氟卡尼可使6例QTfc、6例QTnc间期值平均延长20ms,减少了恶性室性心律失常发生,P<0.05;除颤器治疗6例SQTS患者在观察的1年中无恶性室性心律失常和死亡发生。结论:短QT间期与恶性室性心律失常有关;利多卡因可转律;奎尼丁、氟卡尼能延长QT间期,可减少恶性室性心律失常发生;ICD能有效防止恶性室性心律失常和死亡的发生。

Objective：To research the short QT interval syndrome and malignant ventricular arrhythmia discussion in a oldaged population.Methods：Measured seventy-two patients common twelve lead electrocardiogram QT Fridercia and QT Nomogram interval in a old-aged population,according to R-R interval and heart rate calculated QT interval correct value（QT Fridercia and QT nomogram）.Relation of QT Fridercia,QT nomogram interval≤300 ms with malignant ventricular arrhythmia in observe.Using lidocane,Quinidine,Flecainide and Implanted cardioverter-debrillator cure cbservation prognoses.Results：QT Fridercia≤300 ms in one year total malignant ventricular arrhythmia was 72.22% and QT Nomogram≤300 ms total malignant ventricular arrhythmia was 72.22%;lidocane reversion rhythm part 83.33%;Quinidine,Flecainide could prolong in terval average value 20 ms of six patients QT Fridercia and six patients QT nomogram,decrease malignant ventricular ar rhythmia happen,P0.05;Implanted cardioverter-debrillator cure six patients short QT interval syndrome in one year during observation non malignant ventricular arrhythmia and mortality happen.Conclusion：Short QT interval and malignant arrhythmia have retation;lidocane can reversion rhythm;Quinidine,Flecainide can prolong QT interval,decrease malignant arrhythmia happen;Implanted cardioverter-debrillator can effective prevent malignant ventricular arrhythmia and mortality happen.