乙型肝炎两种血清学模式患者肝功能及体液免疫水平的调查

Investigation of humoral immunity and Hepatic function in Two groups of the Patients with Type B hepatitis

目的调查乙型肝炎中HBsAg、HBeAg、HBcAb阳性(简称HBeAg阳性组)以及HBsAg、HBeAb、HBcAb阳性(简称HBeAb阳性组)患者肝功能、体液免疫水平并与正常人群进行比较,探讨临床价值。方法应用罗氏COBAC6000电化学发光分析仪进行乙肝两对半的定量检测,肝功能、体液免疫水平的测定在日立7600全自动生化分析仪上进行。结果 (1)疾病组血清中的谷丙转氨酶(ALT)、谷草转氨酶(AST)、同型半胱氨酸(HCY)水平均显著高于对照组(P<0.01),总蛋白(TP)、白蛋白(ALB)水平低于对照组(P<0.05),两患者组TP、ALB较对照组有所降低(P<0.05),GLOB水平略高(P<0.05)两组间ALB、GLOB水平存在差异(P<0.05)。HBeAg阳性组血清中ALT、AST显著高于HBeAb阳性组(P<0.01)。(2)HBeAb阳性组血清中的补体C3、C4、免疫球蛋白G(IgG)、C反应蛋白(CRP)水平显著高于对照组(P<0.01),免疫球蛋白A(IgA)水平略高(P<0.05)。HBeAg阳性组CRP水平显著高于对照组(P<0.01),IgG水平略高(P<0.05)。HBeAb阳性组CRP水平明显高于HBeAg阳性组(P<0.01),且IgG、C3、C4水平也略高(P<0.05)。结论患者均存在肝损害、体液免疫亢进,相比之下HBeAb阳性组炎症更为严重、体液免疫更为亢进,肝损害可能更大。

Objective To investigate humoral immunity and hepatic function of patients of two groups,discuss clinical value.Group one is the patients with HBsAg,HBeAg and HBcAb positive;Group two is the patients with HBsAg,HBeAb and HBcAb positive.Methods COBAS 6000 analyzer was run to detect immunity marker of the patients.HITACHI 7600 blood biochemical analyzer was used to extract other data.Results （1）Compared with normal controls the levels of ALT and AST and HCY in all the patients were significantly highered（P0.01）,the levels of TP、ALB were lowered（P0.05）.In the group one the levels of ALT and AST were markedly highered than the group two（P0.01）.（2）In the group two the levels of C3、C4、IgG、CRP were highered than normals（P0.01）,meanwhile they were highered than the group one too.Conclusion There were injury of liver and accentuation of humoral immunity in patients.In the group two inflammation and accentuation of humoral immunity were heavier than the group one.The injury of liver was the same perhaps.