期刊文献+

凋亡相关基因在喉鳞型细胞癌的研究进展 被引量:1

下载PDF
导出
摘要 喉癌约占全身恶性肿瘤的5.7%~7.6%,90%以上的喉癌病理类型是鳞状细胞癌。喉鳞型细胞癌(LSCC)的临床表现包括声音嘶哑、喉痛、呼吸困难或痰中带血:并常伴有颈部肿块。研究证明,喉癌的发生、发展是一个长时间、多阶段的过程。经由正常细胞至肿瘤形成的过程中,癌基因的激活和抑癌基因的失活是细胞癌变的分子学基础,细胞周期中的多种调节因子参与细胞的癌变。
作者 赵坚 沈伟
出处 《老年医学与保健》 CAS 2010年第5期310-312,共3页 Geriatrics & Health Care
  • 相关文献

参考文献22

  • 1Nadal A,Cardesa A.Molecular biology of laryngeal squamous cellcarcinoma[J].Virchows Arch,2003,442 (1):1-7.
  • 2Busquets JM,Garcia HA,Trinidad-Pinedo J,et al.Clinicopathologic characteristics of head and neck squamous cell carcinoma in Puerto Ricans[J].P R Heahh Sci J,2003,22 (3):259-264.
  • 3Kim SG,Hong SJ,Kwon KW,et al.The expression of p53,p16,cyclin DI in esophageal squamous cell carcinoma and esophageal dysplasia[J].Korean J Gastroenterol,2006,48 (4):269-276.
  • 4Auerkari EI.Methylation of tumor suppressor genes p16 (INK4a),p27 (Kipl) and E-cadherin in carcinogenesis[J].Oral Oncology,2006,42 (1):5-13.
  • 5Krecicki T.Smigiel R,Fraczek M,et al.Studies of the cell cycle regulatory proteins Pl 6,cyclinD1 and retinoblastoma protern in laryngeal carcinoma tissue[J].J Laryngol Otol,2004,118:676-680.
  • 6Mira AC,Mita MM,Nawrocki ST,et al.Survivin:key regulator of mitosis and apoptosis and novel target for cancer therapeutics[J].ClinCancerRes,2008,14(16):5000-5005.
  • 7Altieri DC.Survivin and LAP proteins in cell-death mecrhanisms[J].Biochem J,2010,430 (2):199-205.
  • 8Schimmer AD.Inhibitor of apoptosis protems:translating basic knowledge into clinical practice[J].Cancer Res,2004,64 (20):7183-7190.
  • 9Aggarwal BB,Ichikawa H.Molecular targets and anticancer potential of indole-3-carbinol and its derivatives[J].Cell Cycle,2005,4 (9):1201-1215.
  • 10Behrami E,Plescia J.Wilkinson JC,et al.Acute ablation of survivm uncover p53-dependent mitotic checkpoint functions and control ofmitochondrial apoptosis[J].Biol Chem,2004,279 (3):2077-2084.

同被引文献4

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部