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糖尿病、降糖治疗和癌症

Diabetes,Glucose-lowering theraphy and Cancer
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摘要 2型糖尿病与癌症之间的关系日益明显,虽然其中机制尚不十分明确,但对这种情况尽可能的及早调查是很重要的,也完全可能的。从一些观察报告显示二甲双胍对癌症有保护作用,而另一方面外源性胰岛素、胰岛素模拟物以及磺脲类药物都有潜在的增加癌症发生的危险。 The relationship between type 2 diabetes and cancer is consistent and reasonably strong.The underlying mechanisms are still not clear,and at this early stage of investigation it is important to consider all possibilities.This has been highlighted by observational studies suggesting a protective effect on cancer outcomes for metformin,but on the other hand a potential increased cancer risk associated with exogenous insulin,insulin analogues and sulfonylurea therapies.
作者 苏苹 郭庆畬
出处 《中国老年保健医学》 2010年第5期5-7,共3页 Chinese Journal of Geriatric Care
关键词 糖尿病 降糖治疗 胰岛素样生长因子(IGF) 癌症 Diabetes Glucose-lowering therapy IGF Cancer
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参考文献19

  • 1Wilson EB,Maher HC.Cancer and tuberculosis with some comments on cancer and other diseases[J].Am J Cancer,1932,16:227-250.
  • 2Pedolsky S,Marble A.Diverse abnormalities associated with diabetes[M].Joslin's diabetes mellitns,1985,12th edn.Philadelphia,USA.
  • 3Currie CJ,Poole CD,Gale EA.The influence of glucose-lowering therapies on cancer risk in type 2 diabetes[J].Diabetologia,2009,52 (9):1766-1777.
  • 4Libby G,Donnelly LA,Donnan PT,et al.New users of metformin are at low risk of incident cancer:a cohort study among people with type 2 diabetes[J].Diabetes Care,2009,32(9):1748-1750.
  • 5Mannucci E,Monami M,Balzi D,et al.Doses of insulin and its analogues and cancer occurrence in insulin-treated type 2 diabetic patients[J].Diabetes Care,2010,33 (9):1997-2003.
  • 6Giovannucci E,Harlan DM,Archer MC,et al.Diabetes and cancer:a consensus report.Diabetes Care,2010,33 (7):1674-1685.
  • 7Hanahan D,Weiberg RA.The hallmarks of cancer[J].Cell,2000,100(1):57-70.
  • 8Samani AA,Yakar S,LeRoith D,et al.The role of the IGF system in cancer growth and metastasis:overview and recent insights[J].Endocr Rev,2007,28(1):20-47.
  • 9Kim JJ,Accili D.Signalling through IGF-1 and insulin receptors:where is the specificity[J].Growth Horm IGF Res,2002,12(2):84-90.
  • 10Iliopoulos D,Hirsch.HA,Strnhl K.An epigenetic switch involving NF-kappa B,Lin 28,Let7 MicroRNA,and IL-6 links inflammation to cell transformation[J].Cell,2009,139(4):639-706.

二级参考文献20

  • 1Lipscombe LL,Goodwin PJ,Zinman B,et al.Diabetes mellitus and breast cancer:a retrospective population-based cohort study[J].Breast Cancer Res Treat,2006,98(3):349-356.
  • 2Calle EE,Rodriuez C,Walker-Thurmond K,et al.Overweight,obesity,and mortality from cancer in a prospectively studied cohort of U.S.adults[J].N Engl J Med,2003,348(17):1625-1638.
  • 3Wang CC,Goalstone ML,Draznin B.Molecular mechanisms of insulin resistance that impact cardiovascular biology[J].Diabetes,2004,53(11):2735-2740.
  • 4Denley A,Wallace JC,Cosgrove LJ,et al.The insulin receptor isoform exon11-(IR-A) in cancer and other diseases:a review[J].Hom Metab Res,2003,35(11-12):778-785.
  • 5Blume-Jensen P,Hunter T.Oncogenic kinase signaling[J].Nature,2001,411 (6835):355-365.
  • 6Bloomgarden ZT.Third annual world congress on the insulin resistance syndrome:associated conditions[J].Diabetes Care,2006,29(9):2165-2174.
  • 7Menendez JA,Vellon L,Lupu R.Antitumoral actions of the anti-obesity drug orlistat (Xenical) in breast cancer cells:blockade of cell cycle progression,promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene[J].Ann Oncol,2005,16(8):1253-1267.
  • 8Ehrmann-Josko A,Sieminska J,Gornicka B,et al.Impaired glucose metabolism in colorectal cancer[J].Scand J Gastroenterol,2006,41(9):1079-1086.
  • 9Stolzenberg-Solomon RZ,Graaubaard BI,Chari S,et al.Insulin,glucose,insulin resistance,and pancreatic cancer in male smokers[J].JAMA,2005,294(22):2872-2878.
  • 10CalleEE,Thun MJ.Obesity and cancer[J].Oncogne,2004,23(38):6365-6378.

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