养血解毒汤对血燥型银屑病患者血清免疫细胞因子的调节

Effect of Yongxue Jiedu Decoction in Serum IFN-γ TNF-α and IL-6 Levels of Xuere Types Syndrome of Psoriasis

目的:探讨养血解毒汤对血热燥型银屑病患者血清白细胞介素IL-6、干扰素IFN-γ和肿瘤坏死因子TNF-α水平的影响,以评价本药的临床疗效和药理机制。方法:随机选取39例血燥型银屑病患者为治疗组,并设正常对照组,观察治疗组治疗前后临床症状及其血中IL-6、IFN-γ、TNF-α水平的变化。结果:血燥型银屑病患者经养血解毒汤治疗后,患者血清IL-6、IFN-γ、TNF-α含量与治疗前相比显著降低(P≤0.01),并且IFN-γ恢复正常。结论:养血解毒汤通过养血润燥、活血通络等药理作用,明显降低IL-6、IFN-γ、TNF-α的血清含量,使患者免疫调节趋向正常。

Objective：To asses drug pharmacological mechanisms,the effects of Yangxue Jiedu in serum cytokines（interleukin,IL-6;interferon,INF-γand tumor necrosis factor,TNF-α）levels in patients of psoriasis were investigated.Methods：Randomly selected 39 xuezao types syndrome of psoriasis were treated with Yangxue Jiedu decoction for two months in treating group,and 30 healthy cases were as a normal control group,and serum IL-6 and IFN-γ,TNF-αlevel change were observed before and after treament.Results：The serum reducing IL-6 and IFN-γlevels were observed in treated by Liangxue Jidu patients of psoriasis（P≤0.01）,TNF-αlevel change tend to reduce.Conclusion：The study suggested that Yangxue Jiedu decoction Yangxuerunzao,Huoxuetongluo pharmacological effect,reducing serm IL-6,IFN-γ,TNF-α content in psoriasis of xuezao types syndrome of patients with normal immune regulation trends.