摘要
目的:探讨养血解毒汤对血热燥型银屑病患者血清白细胞介素IL-6、干扰素IFN-γ和肿瘤坏死因子TNF-α水平的影响,以评价本药的临床疗效和药理机制。方法:随机选取39例血燥型银屑病患者为治疗组,并设正常对照组,观察治疗组治疗前后临床症状及其血中IL-6、IFN-γ、TNF-α水平的变化。结果:血燥型银屑病患者经养血解毒汤治疗后,患者血清IL-6、IFN-γ、TNF-α含量与治疗前相比显著降低(P≤0.01),并且IFN-γ恢复正常。结论:养血解毒汤通过养血润燥、活血通络等药理作用,明显降低IL-6、IFN-γ、TNF-α的血清含量,使患者免疫调节趋向正常。
Objective:To asses drug pharmacological mechanisms,the effects of Yangxue Jiedu in serum cytokines(interleukin,IL-6;interferon,INF-γand tumor necrosis factor,TNF-α)levels in patients of psoriasis were investigated.Methods:Randomly selected 39 xuezao types syndrome of psoriasis were treated with Yangxue Jiedu decoction for two months in treating group,and 30 healthy cases were as a normal control group,and serum IL-6 and IFN-γ,TNF-αlevel change were observed before and after treament.Results:The serum reducing IL-6 and IFN-γlevels were observed in treated by Liangxue Jidu patients of psoriasis(P≤0.01),TNF-αlevel change tend to reduce.Conclusion:The study suggested that Yangxue Jiedu decoction Yangxuerunzao,Huoxuetongluo pharmacological effect,reducing serm IL-6,IFN-γ,TNF-α content in psoriasis of xuezao types syndrome of patients with normal immune regulation trends.
出处
《辽宁中医药大学学报》
CAS
2010年第11期69-71,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
北京市科技计划项目(Y0905002040191)