银杏叶制剂治疗不稳定型心绞痛随机对照试验系统评价

Systematic Review on Randomized Controlled Trials for Treatment of UAP by Ginkgo Extract

目的:评价银杏叶制剂对比其他制剂治疗不稳定型心绞痛的疗效及应用安全性。方法:采用系统评价的方法,采用计算机检索搜集银杏叶制剂治疗不稳定型心绞痛的随机对照试验(RCT),并进行分析。结果:共纳入23个RCT,2494例患者。行Meta分析显示银杏叶制剂组临床症状有效率优于对照组,差异有统计学意义;因多数研究仅报道了"未见不良反应"字样,故未作Meta分析以了解组间事件发生率及不良反应情况。结论:现有证据支持银杏叶制剂治疗不稳定型心绞痛具有较好疗效,但尚需进行设计合理、执行严格、多中心大样本且随访时间足够的随机对照试验进一步证实结论。

Objective：To investigate and evaluate the current situation of randomized controlled trials on Ginkgo for UAP,and evaluate the curative effect and safety of Ginkgo in treatment of UAP.Methods：Searching the related database of China and other countries systematically for the published clinical studies of randomized controlled trials on Ginkgo for unstable angina from 1994 to June 2008,and we assessed each included studies using the improved Jadad scale,the revised CONSORT for TCM,then meta-analyses were performed for the included studies.Results：A total of 23 studies involving 2494 patients met the inclusion criteria.The meta-analysis with the combined clinical effective rate had statistically differences between the treatment of Ginkgo and other drugs.Conclusion：The evidece with all the included studies shows that Ginkgo is efficacious for UAP.However,restricted by the quality of included studies,it is necessary to conduct rigorous well-designed clinical trials with large sample.