自身免疫性葡萄膜炎发病机制的研究进展

Advances in pathogenesis of autoimmune uveitis

葡萄膜炎是一类严重损害视功能的炎症性疾病,其病因和发病机制尚不完全清楚。感染、外伤、肿瘤、自身免疫反应均可引起,其中以自身免疫反应引起者最为常见。效应性的Ⅰ型辅助性T细胞(helper T lymphocyte 1,Th1)和Th17,调节性T细胞(regulatory T cells,Tr)群失去平衡是自身免疫反应性葡萄膜炎发病的主要机制。此外,遗传易感性也是此种葡萄膜炎发生的一个重要机制。

Uveitis is a group of inflammatory diseases causing serious impairment of visual function.The precise etiology and pathogenesis remain unclear.It can be induced by infection,trauma,tumor or autoimmune response,of which autoimmune response is the most common.Accumulating evidence shows the imbalance of effective helper T lymphocyte 1（Th1）,Th17 and regulatory T cells（Tr） is the predominant pathogenesis.In addition,genetic predisposition has also been implicated to be involved in the pathogenesis of uveitis.