牛蒡子颗粒联合西医治疗糖尿病肾病的临床观察

Clinical observation on treatment of diabetic nephropathy with Fructus Arctii Granula

目的观察牛蒡子颗粒治疗糖尿病肾病患者的临床疗效。方法选择糖尿病肾病Ⅲ期或Ⅳ期患者共35例,分为治疗组(18例)和对照组(17例),两组均先给予包括糖尿病教育、饮食、运动、降糖、降压、调脂药物的基础治疗,治疗组加用牛蒡子颗粒治疗,疗程8周。比较两组治疗前后的24小时尿蛋白及尿微量白蛋白。结果两组治疗后尿蛋白定量均较治疗前有所降低,但组间比较差异无统计学意义(P>0.05);治疗后尿微量白蛋白定量,治疗组比治疗前降低(P<0.05),而对照组比治疗前增高(P<0.05),两组间比较差异也有统计学意义(P<0.05)。结论牛蒡子颗粒联合西医治疗对减少糖尿病肾病患者尿微量白蛋白具有协同增效作用。

Objective To observe the clinical effect of Fructus Arctii Granula in the treatment of diabetic nephropathy.Methods A total of 35 patients with stage Ⅲ or stage Ⅳ diabetic nephropathy were enrolled in this trial.They were randomly divided into two groups,intervention group and control group.The therapeutic course was 8 weeks.Changes of urinary protein and urinary microalbumin before and after treatment of the two groups were observed and compared.Results Urinary protein of both two groups decreased after treatment.Difference was not significant （P 0.05）.Urinary microalbumin in intervention group significantly reduced after treatment （P 0.05）,while that significantly increased in control group （P 0.05）.Difference between two groups was significant （P 0.05）.Conclusion Fructus Arctii Granula has cooperative and synergistic effect for reducing urinary microalbumin in diabetic nephropathy patients.