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PTEN抑癌机制及其对皮肤肿瘤的作用研究进展 被引量：2

Mechanism of PTEN tumor suppressor and its effect on cutaneous tumor
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摘要 肿瘤抑制基因PTEN(Phosphatase and tension homologue deleted on chromosome ten)的编码蛋白具有蛋白酪氨酸磷酸化酯酶(PTPs)活性,在细胞的生长、增殖、分化、凋亡、粘附、迁移和血管生长等许多生理过程中发挥重要作用。已有研究表明,该基因的突变及失活与多种肿瘤的形成密切相关。本文就PTEN抑癌机制及其在皮肤肿瘤中的表达和研究进展进行简要综述。
作者 沈金翠 李灵
机构地区 泸州医学院 四川省医学科学院 四川省人民医院皮肤病性病研究所
出处 《实用医院临床杂志》 2010年第6期142-144,共3页 Practical Journal of Clinical Medicine
基金 四川省卫生厅科研基金资助项目(编号:070084)
关键词 皮肤肿瘤 肿瘤抑制基因 PTEN
分类号 R341 [医药卫生—基础医学] R739.5 [医药卫生—肿瘤]
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二级参考文献73

  • 1沈权,陈泽,刘旭萍,邢海燕,王敏,王建祥.抑癌基因PTEN mRNA在白血病细胞中的表达及意义[J].中华血液学杂志,2005,26(8):493-496. 被引量：20
  • 2王桂芳,毛荣军,杨继清,潘勇权.宫颈鳞癌中PTEN蛋白表达的临床意义[J].临床肿瘤学杂志,2006,11(6):422-424. 被引量：2
  • 3陈葆国,朱敏,罗文达,颜卫华,周美英,李伯利,陶丹丹.骨髓增生异常综合征PTEN基因表达和Akt磷酸化水平的相关性研究[J].中华血液学杂志,2007,28(7):470-473. 被引量：8
  • 4Fujiwara Y,Hoon DS,Yamada T,et al.PTEN/MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinoma.Jpn J Cancer Res,2000,91(3):287-92.
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  • 10Ginn-Pease ME,Eng C.Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF27 cells.Cancer Res,2003,63(2):282-6.

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同被引文献62

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实用医院临床杂志
2010年 第6期

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