都可喜联合尼莫地平治疗血管性认知障碍的临床观察

Duxil Nimodipine Treatment of Vascular Cognitive Impairment Clinical Observation

目的旨在探讨都可喜联合尼莫地平治疗血管性认知障碍的疗效。方法 2组均给予常规治疗,包括降压、控制血糖,降纤、脑保护剂等。观察组在常规治疗基础上加用都可喜2片/d,尼莫地平120mg/d,连续12周,对照组未给予尼莫地平。在服尼莫地平治疗期间停服其他钙离子拮抗剂及其他对治疗产生影响的药物。比较2组患者的MMSE、MoCA评分。结果治疗12周后,观察组MMSE、MoCA评分别较治疗前有显著变化,经统计学分析,差异有显著性（P〈0.01）;对照组MMSE、HDS评用药前后差异无显著性（P〉0.05）。治疗过程中2组均未出现严重副作用,仅观察组出现2例恶心、腹胀等消化道症状,经对症治疗后缓解,未影响用药疗程。结论都可喜联合尼莫地平治疗血管性认知障碍疗效确切,合理使用改善认知功能药物,进行积极的药物干预和生活方式的改善,可以延缓老年痴呆的发生甚至不发生。

Objective To explore both gratifying and nimodipine treatment of vascular cognitive disorder.Methods The two groups were given conventional treatment,including blood pressure,control blood sugar,lower fiber,brain protective agent.The treatment group therapy based on the use Duxil 2/d,nimodipine 120mg/d,for 12 weeks,control group not given nimodipine.During nimodipine treatment in the service stop taking other calcium antagonists and other drugs that affect treatment.The differences in MMSE,MoCA score.Results After 12 weeks of the observation group MMSE,MoCA assessment were compared before treatment were significantly changed by the statistical analysis,the difference was significant （P0.01）;control group,MMSE,HDS evaluation before and after treatment the difference was not significant （P0.05）.Course of treatment,both groups no serious side effects,only the observation group were 2 cases of nausea,bloating and other gastrointestinal symptoms,were relieved by symptomatic treatment,drug treatment was not affected.Conclusion Both gratifying and nimodipine treatment of vascular cognitive impairment is effective,rational use of drugs to improve cognitive function,active drug intervention and lifestyle improvements,can delay the occurrence of dementia did not even happen.