食管癌患者手术治疗前后血清Hcy、IGF-Ⅱ和TSGF检测的临床意义

Clinical Significance of Determination of Changes of Serum Hcy,IGF-Ⅱ and TSGF Levels After Operation in Patients with Esophageal Cancer

目的:探讨了食管癌患者手术治疗前后血清Hcy、IGF-Ⅱ和TSGF水平的变化及意义。方法:应用免疫法和放射免疫分析对33例食管癌患者进行了手术治疗前后血清Hcy、IGF-Ⅱ和TSGF检测,并与35名正常人作比较。结果:食管癌患者在手术前血清Hcy、IGF-Ⅱ和TSGF水平非常显著地高于正常人组(P<0.01)手术后6个月未复发的29例中明显下降接近于正常人组,而复发的4例,其数值又回升至手术前水平(P<0.05)。结论:检测食管癌患者血清Hcy、IGF-Ⅱ和TSGF水平的变化可作为诊断和疗效观察的参考。

Objective To study the changes of serum Hcy,IGF-Ⅱ and TSGF levels after operation in patients with esophageal cancer.Methods Serum Hcy （with immuno-chemistry） ,IGF-Ⅱ（with RIA） and TSGF （with biochemistry） levels were determined in 33 patients with esophageal cancer both before and after operation as well as in 35 controls.Results Before operation,serum： Hcy,IGF-Ⅱ and TSGF levels in the patients were significantly higher than those in the controls （P〈 0.01） .After operation in 29 cases without recurrence at 6 months,the levels remained dropped markedly and approached those in controls.However in the 4 patients with recurrence,the levels increased again,approaching those before operation.Conclusion Serum levels of Hcy,IGF-Ⅱ and TSGF might be useful for diagnosis and predicting therapeutic efficacy after operation in patients with esophageal cancer.